MUTATIONS OF RAS GENE FAMILY IN SPECIMENS OF BLADDER CANCER

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KARIMIANPOUR N.; MOUSAVI SHAFAEI P.; ZIAEI A.A.; AKBARI M.T.; POURMAND GH.R.; ABEDI A.R.; AHMADI ALI; AFSHIN ALAVI H.

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Journal Paper

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Journal: UROLOGY JOURNAL Year:2008 | Volume:5 | Issue:4 Page(s): 237-242

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Title

MUTATIONS OF RAS GENE FAMILY IN SPECIMENS OF BLADDER CANCER

Author(s)

Keywords

BLADDER NEOPLASMS

ONCOGENES

RAS GENES

CODON

POLYMERASE CHAIN REACTION

RESTRICTION FRAGMENT LENGTH POLYMORPHISM

Abstract

Introduction: Studies have shown different types of RAS mutations in human bladder tumors with a wide range of mutation frequencies in different patient populations. This study aimed to assess the frequency of specific-point mutations in the RAS gene family of a group of Iranian patients with bladder cancer. Methods: We examined the tumor specimens of 35 consecutive patients with transitional cell carcinoma. The DNA samples were evaluated for the occurrence of HRAS, KRAS, and NRAS activation using a POLYMERASE CHAIN REACTION-restriction fragment length polymorphism technique. Results: None of the patients had mutations in the RAS gene family "hot spots" including CODONs 12, 13, and 61. Conclusion: We failed to find RAS mutations in our bladder tumor samples. These observations may reflect the involvement of different etiological factors in the induction of bladder tumor of which RAS mutation might not be present in all populations.

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APA: Copy

KARIMIANPOUR, N., MOUSAVI SHAFAEI, P., ZIAEI, A.A., AKBARI, M.T., POURMAND, GH.R., ABEDI, A.R., AHMADI, ALI, & AFSHIN ALAVI, H.. (2008). MUTATIONS OF RAS GENE FAMILY IN SPECIMENS OF BLADDER CANCER. UROLOGY JOURNAL, 5(4), 237-242. SID. https://sid.ir/paper/270853/en

Vancouver: Copy

KARIMIANPOUR N., MOUSAVI SHAFAEI P., ZIAEI A.A., AKBARI M.T., POURMAND GH.R., ABEDI A.R., AHMADI ALI, AFSHIN ALAVI H.. MUTATIONS OF RAS GENE FAMILY IN SPECIMENS OF BLADDER CANCER. UROLOGY JOURNAL[Internet]. 2008;5(4):237-242. Available from: https://sid.ir/paper/270853/en

IEEE: Copy

N. KARIMIANPOUR, P. MOUSAVI SHAFAEI, A.A. ZIAEI, M.T. AKBARI, GH.R. POURMAND, A.R. ABEDI, ALI AHMADI, and H. AFSHIN ALAVI, “MUTATIONS OF RAS GENE FAMILY IN SPECIMENS OF BLADDER CANCER,” UROLOGY JOURNAL, vol. 5, no. 4, pp. 237–242, 2008, [Online]. Available: https://sid.ir/paper/270853/en

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