مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

295
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

210
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

PREVENTION OF URINARY TRACT INFECTION WITH OXIMACRO®, A CRANBERRY EXTRACT WITH A HIGH CONTENT OF A-TYPE PROANTHOCYANIDINS: A PRE-CLINICAL DOUBLE-BLIND CONTROLLED STUDY (MISCELLANEOUS)

Pages

  2640-2649

Abstract

 Purpose: URINARY TRACT INFECTIONS (UTIs) are widespread and affect a large portion of the human population. Cranberry juices and extracts have been used for UTI prevention due to their content of bioactive proanthocyanidins (PACs), particularly of the A type (PAC-A). Controversial clinical results obtained with cranberry are often due to a lack of precise determination and authentication of the PAC-A content. This study used OximacroÒ (Biosfered S.r.l., Turin, Italy), a cranberry extract with a high content of PAC-A, to prevent UTIs in female and male volunteers.Materials and Methods: The OximacroÒ PACs content was assayed using the Brunswick Laboratories 4-dimethylaminocinnamaldehyde (BL-DMAC) method, and the dimer and trimer PACs-A and PACs-B percentages were determined via high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS). A balanced group of female (ranging from 19 to over 51 years) and male volunteers (over 51 years) was divided into two groups. The experimental group received 1 capsule containing OximacroÒ (36 mg PACs-A) twice per day (morning and evening) for 7 days, and the placebo group was given the same number of capsules with no PACs.Results: Analysis of OximacroÒ revealed a high total PAC content (372.34 mg/g ± 2.3) and a high percentage of PAC-A dimers and trimers (86.72% ± 1.65). After 7 days of OximacroÒ administration, a significant difference was found between the placebo and OximacroÒ groups for both females (Mann-Whitney U -test=875, P<.001, n=60) and males (Mann-Whitney U -test=24, P=.016, n=10). When the female and male age ranges were analysed separately, the female age range 31-35 showed only slightly significant differences between the placebo and OximacroÒ groups (Mann-Whitney U -test=20.5, P=.095, n=10), whereas all other female age ranges showed highly significant differences between the placebo and OximacroÒ groups (Mann-Whitney U -test=25, P=.008, n=10). Furthermore, colony forming unit/mL counts from the urine cultures showed a significant difference (P<.001) between the experimental and the placebo groups (SD difference=51688, df=34, t=-10.27, Dunn-Sidak Adjusted P<.001, Bonferroni Adjusted P<.001).Conclusion: Careful determination of the total PAC content using the BL-DMAC method and the authentication of PACs-A with mass spectrometry in cranberry extracts are necessary to prepare effective doses for UTI prevention. A dose of 112 mg OximacroÒ containing 36 mg PACs-A was found to be effective in preventing UTIs when used twice per day for 7 days.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    OCCHIPINTI, ANDREA, GERMANO, ANTONIO, & MAFFEI, MASSIMO E.. (2016). PREVENTION OF URINARY TRACT INFECTION WITH OXIMACRO®, A CRANBERRY EXTRACT WITH A HIGH CONTENT OF A-TYPE PROANTHOCYANIDINS: A PRE-CLINICAL DOUBLE-BLIND CONTROLLED STUDY (MISCELLANEOUS). UROLOGY JOURNAL, 13(2), 2640-2649. SID. https://sid.ir/paper/271018/en

    Vancouver: Copy

    OCCHIPINTI ANDREA, GERMANO ANTONIO, MAFFEI MASSIMO E.. PREVENTION OF URINARY TRACT INFECTION WITH OXIMACRO®, A CRANBERRY EXTRACT WITH A HIGH CONTENT OF A-TYPE PROANTHOCYANIDINS: A PRE-CLINICAL DOUBLE-BLIND CONTROLLED STUDY (MISCELLANEOUS). UROLOGY JOURNAL[Internet]. 2016;13(2):2640-2649. Available from: https://sid.ir/paper/271018/en

    IEEE: Copy

    ANDREA OCCHIPINTI, ANTONIO GERMANO, and MASSIMO E. MAFFEI, “PREVENTION OF URINARY TRACT INFECTION WITH OXIMACRO®, A CRANBERRY EXTRACT WITH A HIGH CONTENT OF A-TYPE PROANTHOCYANIDINS: A PRE-CLINICAL DOUBLE-BLIND CONTROLLED STUDY (MISCELLANEOUS),” UROLOGY JOURNAL, vol. 13, no. 2, pp. 2640–2649, 2016, [Online]. Available: https://sid.ir/paper/271018/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button