Investigation of Renal Cell Carcinoma by Contrast-Enhanced Ultrasound-Predictive Value of Time Intensity Curve Analysis in Establishing Local Tumor Invasion and Stage: A Pilot Study

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Tamas Szora Attila; Socaciu Mihai; Crisan Nicolae; Dobrota Florentin; Prundus Paul; Bungardean Catalina; Buruian Mircea; Coman Ioan; Opincariu Iulian; BADEA RADU

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Journal: UROLOGY JOURNAL Year:2015 | Volume:12 | Issue:3 Page(s): 2173-2181

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Title

Investigation of Renal Cell Carcinoma by Contrast-Enhanced Ultrasound-Predictive Value of Time Intensity Curve Analysis in Establishing Local Tumor Invasion and Stage: A Pilot Study

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Keywords

carcinoma

renal cell

radiography

kidney neoplasms

sensitivity and specificity

image interpretation

ultrasonography

contrast media

methods

Abstract

Purpose: Contrast-enhanced ultrasound (CEUS) allows for real-time examination of signal intensity changes in a region of interest (ROI) and quantification of contrast agent kinetics. This study assessed the predictive ability of time-intensity curve (TIC) parameters for local tumor invasion and T stage of renal cell carcinoma (RCC). Materials and methods: Renal tumors in 41 patients were examined by CEUS. Thirty-two met the inclusion criteria, with a total of 33 tumors (27 clear cell, 4 chromophobe, and 2 papillary type I). Nineteen (57. 6%) tumors were included in group A (stages pT1 and pT2) and 14 (42. 4%) in group B (stage pT3). ROIs were established as: whole tumor (TuW); tumor area with the highest signal intensity (TuMAX) and renal cortex (Ref). The TIC parameters for each ROI were calculated as below: peak signal intensity, time to peak (TTP), rise time (RT), and mean transit time (MTT). They were analyzed as a whole value for each ROI and as a ratio between the different ROIs. Results: There were significant differences between the tumors invading and not invading the renal sinus fat for TTP (TuW/Ref) [0. 98 (0. 67– 1. 25) vs. 1. 18 (1. 08– 1. 3), P <. 05]. For differentiation between groups A and B, the following ratios were proven as predictors by univariate regression analysis: TTP (TuMAX/TuW); MTT (Tu-MAX/TuW); RT (TuMAX/TuW) (P =. 03, P =. 01 and P =. 02, respectively). The value derived from the Receiver Operating Characteristic (ROC) curve for RT (TuMAX/TuW) was 0. 8 with sensitivity = 78. 6%, specificity = 89. 5%, and cutoff value of > 0. 91. Conclusion: TIC parameters were predictors of locally noninvasive and invasive RCC.

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APA: Copy

Tamas Szora, Attila, Socaciu, Mihai, Crisan, Nicolae, Dobrota, Florentin, Prundus, Paul, Bungardean, Catalina, Buruian, Mircea, Coman, Ioan, Opincariu, Iulian, & BADEA, RADU. (2015). Investigation of Renal Cell Carcinoma by Contrast-Enhanced Ultrasound-Predictive Value of Time Intensity Curve Analysis in Establishing Local Tumor Invasion and Stage: A Pilot Study. UROLOGY JOURNAL, 12(3), 2173-2181. SID. https://sid.ir/paper/271042/en

Vancouver: Copy

Tamas Szora Attila, Socaciu Mihai, Crisan Nicolae, Dobrota Florentin, Prundus Paul, Bungardean Catalina, Buruian Mircea, Coman Ioan, Opincariu Iulian, BADEA RADU. Investigation of Renal Cell Carcinoma by Contrast-Enhanced Ultrasound-Predictive Value of Time Intensity Curve Analysis in Establishing Local Tumor Invasion and Stage: A Pilot Study. UROLOGY JOURNAL[Internet]. 2015;12(3):2173-2181. Available from: https://sid.ir/paper/271042/en

IEEE: Copy

Attila Tamas Szora, Mihai Socaciu, Nicolae Crisan, Florentin Dobrota, Paul Prundus, Catalina Bungardean, Mircea Buruian, Ioan Coman, Iulian Opincariu, and RADU BADEA, “Investigation of Renal Cell Carcinoma by Contrast-Enhanced Ultrasound-Predictive Value of Time Intensity Curve Analysis in Establishing Local Tumor Invasion and Stage: A Pilot Study,” UROLOGY JOURNAL, vol. 12, no. 3, pp. 2173–2181, 2015, [Online]. Available: https://sid.ir/paper/271042/en

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