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Information Journal Paper

Title

The α 1 Adrenoceptor Antagonist Tamsulosin for the Treatment of Voiding Symptoms Improves Nocturia and Sleep Quality in Women

Pages

  1636-1641

Abstract

 Purpose: Nocturia is the main cause of disturbance of sleep maintenance and negatively impacts quality of life (QoL). We assessed the effects of the α 1-adrenoceptor antagonist, tamsulosin, on nocturia and quality of sleep, for the treatment of lower urinary tract symptoms (LUTS) in women with a maximal flow rate (Qmax) less than 15 mL/sec. Materials and Methods: From January 2008 to December 2009, women with LUTS [Qmax ≤ 15 mL/s, International Prostate Symptom Score (IPSS) ≥ 8] and nocturia (void/night ≥ 1) were selected for this study. Two hundred ninety six patients completed voiding diary, a questionnaire on the Medical Outcomes Study (MOS) sleep scale and underwent follow-up evaluation after 4 weeks of treatment (tamsulosin, 0. 2 mg, once daily). Effectiveness was assessed by analysis of the IPSS, the bother score, the Qmax, and postvoid residual urine (PVR). Results: The mean number of voids per night was 2. 66 ± 1. 3, and the total IPSS and bother scores were 15. 2 ± 8. 9 and 3. 4 ± 1. 2, respectively. Clinical parameters, including the IPSS, the bother score, the Qmax and the PVR, improved significantly from baseline after treatment (P <. 05). The change in nocturia was-1. 12 (P <. 05). Concerning sleep quality, the sleep problem index showed a significant decrease. Among the items on the sleep subscale, sleep disturbance, somnolence, and sleep adequacy were significantly changed (P <. 05). Conclusion: The α 1-adrenoceptor antagonist tamsulosin significantly improved nocturia and sleep quality as well as LUTS in women with low Qmax.

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    APA: Copy

    Kim, Sun Ouck, Choi, Hyang Sik, & Kwon, Dongdeuk. (2014). The α 1 Adrenoceptor Antagonist Tamsulosin for the Treatment of Voiding Symptoms Improves Nocturia and Sleep Quality in Women. UROLOGY JOURNAL, 11(3), 1636-1641. SID. https://sid.ir/paper/271106/en

    Vancouver: Copy

    Kim Sun Ouck, Choi Hyang Sik, Kwon Dongdeuk. The α 1 Adrenoceptor Antagonist Tamsulosin for the Treatment of Voiding Symptoms Improves Nocturia and Sleep Quality in Women. UROLOGY JOURNAL[Internet]. 2014;11(3):1636-1641. Available from: https://sid.ir/paper/271106/en

    IEEE: Copy

    Sun Ouck Kim, Hyang Sik Choi, and Dongdeuk Kwon, “The α 1 Adrenoceptor Antagonist Tamsulosin for the Treatment of Voiding Symptoms Improves Nocturia and Sleep Quality in Women,” UROLOGY JOURNAL, vol. 11, no. 3, pp. 1636–1641, 2014, [Online]. Available: https://sid.ir/paper/271106/en

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