Anterior Apical Cores in the Initial Prostate Biopsy do not Increase Detection Rate of Significant Prostate Cancer

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Ekin Rahmi Gokhan; Zorlu Ferruh; Akarken Ilker; Yildirim Zubeyde; TARHAN HUSEYIN; Koc Gokhan; Kucuk Ulku; Bayol Umit

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Journal: UROLOGY JOURNAL Year:2015 | Volume:12 | Issue:2 Page(s): 2084-2089

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Title

Anterior Apical Cores in the Initial Prostate Biopsy do not Increase Detection Rate of Significant Prostate Cancer

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Keywords

prostatic neoplasms

diagnosis

biopsy

needle

methods

prostate

pathology

Abstract

Purpose: To examine the effect of routine sampling anterior apical cores in the initial prostate biopsy among patients that 14-cores of prostate biopsy (PB) planned. Materials and methods: Five-hundred twenty-eight patients with increased prostate-specific antigen (PSA) levels and/or abnormal digital rectal examination underwent transrectal ultrasound and initial PB between November 2012 and October 2013. We performed routine 12-cores extended PB, plus 2 anterior apex samples that were taken from the junction of urethra and apex of the prostate. Site-specific and unique cancer detection rate, tumor characteristics, the presence of clinically insignificant prostate cancer (PCa) (clinical stage ≤ T1, serum PSA level of < 10 ng/mL, biopsy Gleason score ≤ 6, number of positive biopsy cores ≤ 3 and no core with > 50% involvement) and biopsy-related pain were evaluated. Results: PCa was detected in 147 of 451 patients (32. 6%). The lateral base of the prostate was the most affected area with 128 of 451 patients (28. 3%), followed by unique cancer detection, with 17 of 40 patients (43. 5%). Anterior apex (n = 6) was in third place after the lateral apex (n = 8). The patients diagnosed by anterior apex cores were all clinically insignificant PCa. The cancer diagnosis rate would be 31% if 12-cores biopsy was used, but the rate was found to be 32. 6% in 14-cores biopsy (P =. 016). Average biopsy pain, right anterior apex biopsy pain, and left anterior apex biopsy pain were found to register at 0. 61, 1. 06 and 1. 08 points in the visual analog scale pain score, respectively. When right and left anterior apex biopsy pain is compared to average biopsy pain, the pain level was found to be statistically significantly higher in the biopsies of right and left anterior apex (P =. 040 and P =. 042, respectively). Conclusion: The gold standard for the diagnosis of PCa is at least 8 cores PB. According to our results, although most PCa diagnosis is carried out with 14-cores PB, it should not be forgotten that these patients might have clinically insignificant PCa.

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APA: Copy

Ekin, Rahmi Gokhan, Zorlu, Ferruh, Akarken, Ilker, Yildirim, Zubeyde, TARHAN, HUSEYIN, Koc, Gokhan, Kucuk, Ulku, & Bayol, Umit. (2015). Anterior Apical Cores in the Initial Prostate Biopsy do not Increase Detection Rate of Significant Prostate Cancer. UROLOGY JOURNAL, 12(2), 2084-2089. SID. https://sid.ir/paper/271215/en

Vancouver: Copy

Ekin Rahmi Gokhan, Zorlu Ferruh, Akarken Ilker, Yildirim Zubeyde, TARHAN HUSEYIN, Koc Gokhan, Kucuk Ulku, Bayol Umit. Anterior Apical Cores in the Initial Prostate Biopsy do not Increase Detection Rate of Significant Prostate Cancer. UROLOGY JOURNAL[Internet]. 2015;12(2):2084-2089. Available from: https://sid.ir/paper/271215/en

IEEE: Copy

Rahmi Gokhan Ekin, Ferruh Zorlu, Ilker Akarken, Zubeyde Yildirim, HUSEYIN TARHAN, Gokhan Koc, Ulku Kucuk, and Umit Bayol, “Anterior Apical Cores in the Initial Prostate Biopsy do not Increase Detection Rate of Significant Prostate Cancer,” UROLOGY JOURNAL, vol. 12, no. 2, pp. 2084–2089, 2015, [Online]. Available: https://sid.ir/paper/271215/en

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