Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

314
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

152
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis

Pages

  4069-4078

Abstract

 Purpose: To evaluate the effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in sub fertile men. Materials and Methods: We conducted a systematic review and meta-analysis. Electronic databases of Medline, Scopus, Google scholar and Persian databases (SID, Iran medex, Magiran, Medlib, Iran doc) were searched from 1966 to December 2016 using a set of relevant keywords including “ folate or folic acid AND (infertility, infertile, sterility)” . All available randomized controlled trials (RCTs), conducted on a sample of sub fertile men with semen analyses, who took oral folic acid or folate plus zinc, were included. Data collected included endocrine parameters and sperm characteristics. Statistical analyses were done by Comprehensive Meta-analysis Version 2. Results: In total, seven studies were included. Six studies had sufficient data for meta-analysis. “ sperm concentration was statistically higher in men supplemented with folate than with placebo (P <. 001)” . However, folate supplementation alone did not seem to be more effective than the placebo on the morphology (P =. 056) and motility of the sperms (P =. 652). folate plus zinc supplementation did not show any statistically different effect on serum testosterone (P =. 86), inhibin B (P =. 84), FSH (P =. 054), and sperm motility (P =. 169) as compared to the placebo. Yet, folate plus zinc showed statistically higher effect on the sperm concentration (P <. 001), morphology (P <. 001), and serum folate level (P <. 001) as compared to placebo. Conclusion: folate plus zinc supplementation has a positive effect on sperm characteristics in sub fertile men. However, these results should be interpreted with caution due to the important heterogeneity of the studies included in this meta-analysis. Further trials are still needed to confirm the current findings.

Cites

References

  • No record.

    • Cite

    APA: Copy

    IRANI, MORVARID, AMIRIAN, MALIHEH, SADEGHI, RAMIN, Le Lez, Justine, & LATIFNEJAD ROUDSARI, ROBAB. (2017). The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis. UROLOGY JOURNAL, 14(5), 4069-4078. SID. https://sid.ir/paper/271330/en

    Vancouver: Copy

    IRANI MORVARID, AMIRIAN MALIHEH, SADEGHI RAMIN, Le Lez Justine, LATIFNEJAD ROUDSARI ROBAB. The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis. UROLOGY JOURNAL[Internet]. 2017;14(5):4069-4078. Available from: https://sid.ir/paper/271330/en

    IEEE: Copy

    MORVARID IRANI, MALIHEH AMIRIAN, RAMIN SADEGHI, Justine Le Lez, and ROBAB LATIFNEJAD ROUDSARI, “The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis,” UROLOGY JOURNAL, vol. 14, no. 5, pp. 4069–4078, 2017, [Online]. Available: https://sid.ir/paper/271330/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top