Prognostic Value of Circulating Tumor Cells in Castration Resistant Prostate Cancer: A Meta-analysis

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Zheng Yuxiao; ZHANG CHENGSI; WU JIE; Cheng Gong; Yang Haiwei; Hua Lixin; Wang Zengjun

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Journal: UROLOGY JOURNAL Year:2016 | Volume:13 | Issue:6 Page(s): 2881-2888

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Title

Prognostic Value of Circulating Tumor Cells in Castration Resistant Prostate Cancer: A Meta-analysis

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Keywords

castration-resistant prostate cancer

circulating tumor cells

hazard ratios

meta-analysis

prognosis

Abstract

Purpose: The prognostic value of circulating tumor cells (CTC) detected in castration-resistant prostate cancer (CRPC) is currently under debate. The aim of our meta-analysis was to evaluate the prognostic effect of CTC and to elucidate whether the detection of CTC in the peripheral blood (PB) of patients diagnosed with CRPC can be used as an independent prognostic factor for survival. Materials and Methods: The Pubmed, Science Citation Index, Cochrane Database, Embase Cell Research database and the references in relevant studies were systematically searched. hazard ratios (HRs) for overall survival (OS) with 95% confidence intervals (CIs), subgroup analysis, sensitivity analysis, meta-regression analysis was pooled and publication bias were conducted. Results: Ten eligible studies enrolling 1206 patients were identified for final analysis. To decrease the heterogeneity of this meta-analysis we excluded two studies after sensitivity analysis. Remained eight studies were enrolled in the pooled analysis and the result revealed that CTC positivity (presence of 5 or more CTCs per 7. 5mL PB) was significantly associated with a poor OS (HR = 2. 76, 95%CI: 2. 28-3. 34, P <. 0001). Conclusion: Our study demonstrated that CTC positivity indicates poor prognosis in patients with CRPC. CTC counts can be used as an independent prognostic factor of survival rate in patients with CRPC.

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APA: Copy

Zheng, Yuxiao, ZHANG, CHENGSI, WU, JIE, Cheng, Gong, Yang, Haiwei, Hua, Lixin, & Wang, Zengjun. (2016). Prognostic Value of Circulating Tumor Cells in Castration Resistant Prostate Cancer: A Meta-analysis. UROLOGY JOURNAL, 13(6), 2881-2888. SID. https://sid.ir/paper/271370/en

Vancouver: Copy

Zheng Yuxiao, ZHANG CHENGSI, WU JIE, Cheng Gong, Yang Haiwei, Hua Lixin, Wang Zengjun. Prognostic Value of Circulating Tumor Cells in Castration Resistant Prostate Cancer: A Meta-analysis. UROLOGY JOURNAL[Internet]. 2016;13(6):2881-2888. Available from: https://sid.ir/paper/271370/en

IEEE: Copy

Yuxiao Zheng, CHENGSI ZHANG, JIE WU, Gong Cheng, Haiwei Yang, Lixin Hua, and Zengjun Wang, “Prognostic Value of Circulating Tumor Cells in Castration Resistant Prostate Cancer: A Meta-analysis,” UROLOGY JOURNAL, vol. 13, no. 6, pp. 2881–2888, 2016, [Online]. Available: https://sid.ir/paper/271370/en

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