Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy

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NASSEH HAMIDREZA; Abdi Sepideh; ROSHANI ALI; KAZEMNEZHAD EHSAN

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Journal: UROLOGY JOURNAL Year:2016 | Volume:13 | Issue:6 Page(s): 2911-2915

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Title

Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy

Author(s)

NASSEH HAMIDREZA | Abdi Sepideh | ROSHANI ALI | KAZEMNEZHAD EHSAN | Issue Writer Certificate

Keywords

acute kidney injury

beta2-microglobulin

extracorporeal shock wave lithotripsy

urinary stone

Abstract

Purpose: This study aims to determine extracorporeal shock wave lithotripsy (ESWL)-induced renal tubular damage and the affecting factors by measuring urinary beta2microglobulin (β 2M) excretion. Materials and Methods: This is a cross-sectional study conducted on 91 patients with renal stones who underwent ESWL during 2012. Urinary beta2microglobulin was measured immediately before and after the procedure for each patient and analyzed based on different variables to evaluate factors affecting ESWL-induced renal tubular injury. Results: Mean ± SD urinary beta2-microglobulin values, before and after ESWL were 0. 08 ± 0. 07 and 0. 22 ± 0. 71 mg/dL respectively, the average difference between which was equal to 0. 14 ± 0. 07 mg/dL. These figures exhibited a 166. 66% rise in the urinary β 2M concentration after ESWL which was statistically significant (P <. 001). Multivariate analysis showed that hypertension (P =. 05) and the history of ESWL (P =. 02) were predictive factors of higher post-ESWL urinary beta2-microglobulin excretion. Conclusion: Urinary excretion of beta2-microglobulin increased significantly immediately after ESWL. These changes could indicate that ESWL is a contributing factor to renal tubular damage. It also seems that in patients with hypertension and a previous history of ESWL the likelihood of this injury is higher than others.

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APA: Copy

NASSEH, HAMIDREZA, Abdi, Sepideh, ROSHANI, ALI, & KAZEMNEZHAD, EHSAN. (2016). Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy. UROLOGY JOURNAL, 13(6), 2911-2915. SID. https://sid.ir/paper/271371/en

Vancouver: Copy

NASSEH HAMIDREZA, Abdi Sepideh, ROSHANI ALI, KAZEMNEZHAD EHSAN. Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy. UROLOGY JOURNAL[Internet]. 2016;13(6):2911-2915. Available from: https://sid.ir/paper/271371/en

IEEE: Copy

HAMIDREZA NASSEH, Sepideh Abdi, ALI ROSHANI, and EHSAN KAZEMNEZHAD, “Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy,” UROLOGY JOURNAL, vol. 13, no. 6, pp. 2911–2915, 2016, [Online]. Available: https://sid.ir/paper/271371/en

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