COMPARISON OF THE EFFECTS OF CLOFIBRATE AND SILAFIBRATE ON SPERM PARAMETERS QUALITY AND SEX HORMONES IN MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Delashoub Masoud; ZIAEE MOJTABA; KHORRAMI ARASH; BANAN KHOJASTEH SEYED MAHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: UROLOGY JOURNAL Year:2018 | Volume:15 | Issue:2 Page(s): 38-43

Download Full-Text

View:

191

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF THE EFFECTS OF CLOFIBRATE AND SILAFIBRATE ON SPERM PARAMETERS QUALITY AND SEX HORMONES IN MALE RATS

Author(s)

Delashoub Masoud | ZIAEE MOJTABA | KHORRAMI ARASH | BANAN KHOJASTEH SEYED MAHDI | Issue Writer Certificate

Keywords

CLOFIBRATE

SILAFIBRATE

SPERMATOGENSIS

RATS

Abstract

Purpose: Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of CLOFIBRATE, called SILAFIBRATE, have shown good lipid lowering effects. This study was designed to assess the role of SILAFIBRATE as a peroxisome proliferator-activated receptors (PPARs) agonist on sperm health and spermatogenesis in adult male RATS. Material and Methods: Seventy male Wistar RATS were randomly allocated into 7 groups: Cl-10, Cl-20, and Cl-40 mg/kg/day (CLOFIBRATE); Si-10, Si-20, and Si-40 mg/kg/day (SILAFIBRATE); and C, control. After a 28-day treatment, all RATS were euthanized. Blood samples were taken for determination of testosterone, total antioxidant capacity, levels of malondialdehyde, and oxidized low-density lipoprotein. Reproductive organs were dissected and spermatozoa collected from the epididymis for analysis. Result: Sperm parameters (count, motility, viability, and morphology) and total serum testosterone decreased significantly in CLOFIBRATE-treated (20 and 40 mg/kg) RATS (P < 0. 05) as compared with normal RATS. Conclusion: We conclude that PPARs agonists have significant adverse effect on sperm viability, motility, and total serum testosterone, and could be harmful for sperm parameters and male reproductive function in RATS.

Cites

No record.

References

No record.

Cite

APA: Copy

Delashoub, Masoud, ZIAEE, MOJTABA, KHORRAMI, ARASH, & BANAN KHOJASTEH, SEYED MAHDI. (2018). COMPARISON OF THE EFFECTS OF CLOFIBRATE AND SILAFIBRATE ON SPERM PARAMETERS QUALITY AND SEX HORMONES IN MALE RATS. UROLOGY JOURNAL, 15(2), 38-43. SID. https://sid.ir/paper/271433/en

Vancouver: Copy

Delashoub Masoud, ZIAEE MOJTABA, KHORRAMI ARASH, BANAN KHOJASTEH SEYED MAHDI. COMPARISON OF THE EFFECTS OF CLOFIBRATE AND SILAFIBRATE ON SPERM PARAMETERS QUALITY AND SEX HORMONES IN MALE RATS. UROLOGY JOURNAL[Internet]. 2018;15(2):38-43. Available from: https://sid.ir/paper/271433/en

IEEE: Copy

Masoud Delashoub, MOJTABA ZIAEE, ARASH KHORRAMI, and SEYED MAHDI BANAN KHOJASTEH, “COMPARISON OF THE EFFECTS OF CLOFIBRATE AND SILAFIBRATE ON SPERM PARAMETERS QUALITY AND SEX HORMONES IN MALE RATS,” UROLOGY JOURNAL, vol. 15, no. 2, pp. 38–43, 2018, [Online]. Available: https://sid.ir/paper/271433/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops