Patient-reported Goal Achievement after Treating Male Benign Prostatic Hyperplasia with Alphaadrenergic Antagonist: A-12week Prospective Multicenter Study

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Kim Bum Soo; Kim Tae Hwan; KIM KI HO; Kim Byung Hoon; Ha Ji Yong; Cho Deok Hyun; Kim Gun Nam; Lee Yoon Hyung; Kim Jae Soo; Jung Hyun Jin; Shin Hong Seok; Song Phil Hyun; Yoon Jong Hyun; Kim Jae Ho; Yoo Eun Sang

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Journal: UROLOGY JOURNAL Year:2019 | Volume:16 | Issue:4 Page(s): 386-391

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Title

Patient-reported Goal Achievement after Treating Male Benign Prostatic Hyperplasia with Alphaadrenergic Antagonist: A-12week Prospective Multicenter Study

Author(s)

Keywords

prostatic hyperplasia

adrenergic alpha-antagonists

drug therapy

lower urinary tract symptoms

patient outcome assessment

Abstract

Purpose: The study was designed to assess and predict patient-reported goal achievement after treatment of benign prostatic hyperplasia (BPH) patients with tamsulosin. Materials and methods: From November 2013 to October 2015, 272 patients initially diagnosed with BPH were prospectively enrolled in nine different centers. Before the treatment, subjective final goals were recorded by all patients. Every four weeks, the treatment outcomes were evaluated using international prostate symptom score (IPSS) and uroflowmetry, and adverse events were recorded. Patient-reported goal achievements were assessed after 12 weeks of treatment. Results: Of the enrolled patients, 179 patients completed the study. The pretreatment patients’ goals included the frequency improvement, nocturia improvement, residual urine sense improvement, well voiding, hesitancy improvement, weak urine stream improvement, urgency improvement, and voiding-related discomfort improvement. Of the 179 patients, 129 patients (72. 1%) reported that they achieved their primary goals after three months of medical therapy. Logistic regression analysis revealed that pretreatment quality of life (OR = 8. 621, 95% CI: 2. 154-9. 834), and improvement of quality of life (OR = 6. 740, 95% CI: 1. 908-11. 490) were independent predictors of patient-reported goal achievement after tamsulosin monotherapy. Conclusion: Overall patient-reported goal achievement after medical therapy for BPH was high and the scores of pretreatment quality of life and improvement of quality of life can be important factors to predict the achievement of treatment goals.

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References

Comparing Monotherapy with Tadalafil or Tamsulosin and Their Combination Therapy in Men with Benign Prostatic Hyperplasia: A Randomized Clinical Trial

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APA: Copy

Kim, Bum Soo, Kim, Tae Hwan, KIM, KI HO, Kim, Byung Hoon, Ha, Ji Yong, Cho, Deok Hyun, Kim, Gun Nam, Lee, Yoon Hyung, Kim, Jae Soo, Jung, Hyun Jin, Shin, Hong Seok, Song, Phil Hyun, Yoon, Jong Hyun, Kim, Jae Ho, & Yoo, Eun Sang. (2019). Patient-reported Goal Achievement after Treating Male Benign Prostatic Hyperplasia with Alphaadrenergic Antagonist: A-12week Prospective Multicenter Study. UROLOGY JOURNAL, 16(4), 386-391. SID. https://sid.ir/paper/271572/en

Vancouver: Copy

Kim Bum Soo, Kim Tae Hwan, KIM KI HO, Kim Byung Hoon, Ha Ji Yong, Cho Deok Hyun, Kim Gun Nam, Lee Yoon Hyung, Kim Jae Soo, Jung Hyun Jin, Shin Hong Seok, Song Phil Hyun, Yoon Jong Hyun, Kim Jae Ho, Yoo Eun Sang. Patient-reported Goal Achievement after Treating Male Benign Prostatic Hyperplasia with Alphaadrenergic Antagonist: A-12week Prospective Multicenter Study. UROLOGY JOURNAL[Internet]. 2019;16(4):386-391. Available from: https://sid.ir/paper/271572/en

IEEE: Copy

Bum Soo Kim, Tae Hwan Kim, KI HO KIM, Byung Hoon Kim, Ji Yong Ha, Deok Hyun Cho, Gun Nam Kim, Yoon Hyung Lee, Jae Soo Kim, Hyun Jin Jung, Hong Seok Shin, Phil Hyun Song, Jong Hyun Yoon, Jae Ho Kim, and Eun Sang Yoo, “Patient-reported Goal Achievement after Treating Male Benign Prostatic Hyperplasia with Alphaadrenergic Antagonist: A-12week Prospective Multicenter Study,” UROLOGY JOURNAL, vol. 16, no. 4, pp. 386–391, 2019, [Online]. Available: https://sid.ir/paper/271572/en

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