FREQUENCY OF A VERY RARE 35DELG MUTATION IN TWO ETHNIC GROUPS OF IRANIAN POPULATIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SASANFAR R.; TOLOUEI A.; HOSEINIPOUR A.; FARHOUD D.D.; DOULATI M.; HOGHOOGHI RAD L.; MONTAZER ZOHOUR M.; GHAEMI M.; POURJAFARI H.; HASHEMZADEH CHALESHTORI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2004 | Volume:33 | Issue:4 Page(s): 26-30

Download Full-Text

View:

437

Download:

388

Cites:

Information Journal Paper

Title

FREQUENCY OF A VERY RARE 35DELG MUTATION IN TWO ETHNIC GROUPS OF IRANIAN POPULATIONS

Author(s)

Keywords

CONNEXIN 26

GJB2

DEAFNESS

MUTATION

AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS

IRAN

Abstract

The 35delG MUTATION in the CONNEXIN 26 gene (Cx26), at the DNFB1 locus is the most common MUTATION in the patients with AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL). We have studied a total of 224 deaf cases from 189 families in two populations of IRAN (Sistan va Bluchestan and Hormozgan provinces) by prescreening nested PCR, polyacrylamide gel electrophoresis and consequent direct sequencing method for all cases. The aim of the present work was to find prevalence of GJB2 mutations in the populations studied. Four different GJB2 mutations including 35delG, W24X, R127H and (V27I + E114 G) were identified in 11 of 189 families (5.8%). Two polymorphisms (V27I and V153I) also were detected in 14 families. A polymorphism S86T was determined in all cases. Homozygote 35delG MUTATION was found only in 1 of 189 families (0.5%).The rate of Cx26 mutations found in this study was lower than other IRANian populations. So the cause of DEAFNESS in the populations studied remains to be detected in other loci or genes.

Cites

AUTOSOMAL RECESSIVE AND SPORADIC NON SYNDROMIC HEARING LOSS AND THE INCIDENCE OF CX26 MUTATIONS IN A PROVINCE OF IRAN

References

Cite

APA: Copy

SASANFAR, R., TOLOUEI, A., HOSEINIPOUR, A., FARHOUD, D.D., DOULATI, M., HOGHOOGHI RAD, L., MONTAZER ZOHOUR, M., GHAEMI, M., POURJAFARI, H., & HASHEMZADEH CHALESHTORI, M.. (2004). FREQUENCY OF A VERY RARE 35DELG MUTATION IN TWO ETHNIC GROUPS OF IRANIAN POPULATIONS. IRANIAN JOURNAL OF PUBLIC HEALTH, 33(4), 26-30. SID. https://sid.ir/paper/272066/en

Vancouver: Copy

SASANFAR R., TOLOUEI A., HOSEINIPOUR A., FARHOUD D.D., DOULATI M., HOGHOOGHI RAD L., MONTAZER ZOHOUR M., GHAEMI M., POURJAFARI H., HASHEMZADEH CHALESHTORI M.. FREQUENCY OF A VERY RARE 35DELG MUTATION IN TWO ETHNIC GROUPS OF IRANIAN POPULATIONS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2004;33(4):26-30. Available from: https://sid.ir/paper/272066/en

IEEE: Copy

R. SASANFAR, A. TOLOUEI, A. HOSEINIPOUR, D.D. FARHOUD, M. DOULATI, L. HOGHOOGHI RAD, M. MONTAZER ZOHOUR, M. GHAEMI, H. POURJAFARI, and M. HASHEMZADEH CHALESHTORI, “FREQUENCY OF A VERY RARE 35DELG MUTATION IN TWO ETHNIC GROUPS OF IRANIAN POPULATIONS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 33, no. 4, pp. 26–30, 2004, [Online]. Available: https://sid.ir/paper/272066/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops