ASSOCIATION OF VARIABLE NUMBER OF TANDEM REPEATS IN ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE WITH CORONARY ARTERY DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALIMI S.; FIROUZRAI M.; NOURMOHAMMADI I.; SHABANI M.; ZAVAREH A.; MOHEBI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2006 | Volume:35 | Issue:4 Page(s): 15-21

Download Full-Text

View:

429

Download:

189

Cites:

Information Journal Paper

Title

ASSOCIATION OF VARIABLE NUMBER OF TANDEM REPEATS IN ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE WITH CORONARY ARTERY DISEASE

Author(s)

Keywords

CORONARY ARTERY DISEASE

NITRIC OXIDE SYNTHASE GENE

POLYMORPHISM

Abstract

Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (eNOS). Since reduced NO synthesis has been implicated in the development of coronary atherosclerosis; we hypothesized that POLYMORPHISMs of NOS gene might be associated with increased susceptibility to this disorder and CORONARY ARTERY DISEASE (CAD). We studied the 27 base pair tandem repeat POLYMORPHISM in intron4 of the endothelial nitric oxide synthase (eNOS) gene in 141 unrelated CAD patients with positive coronary angiograms in Shahid Rajaee Heart Hospital and 159 age matched control subjects without a history of symptomatic CAD. The study protocol was approved by the Iran University of Medical Sciences Ethics Committee. The eNOS gene intron4a/b VNTR POLYMORPHISM was analyzed by polymerase chain reaction. The plasma lipids levels and other risk factors were also determined. The genotype frequencies for eNOS4b/b, eNOS4a/b and eNOS4a/a were 68.8, 29.1 and 2.1% in CAD subjects, and 81, 18.4 and 0.6 % in control subjects, respectively. The genotype frequencies differed significantly between the two groups (χ²= 6.38 P= 0.041). The frequency of the allele was 16.7% in CAD subjects and 9.8% in control subjects and was significantly higher in the patients (χ²= 6.18 P= 0.013, odds ratio= 1.84). Plasma lipids, except HDL-C were also remarkable increased in CAD group.

Cites

No record.

References

Cite

APA: Copy

SALIMI, S., FIROUZRAI, M., NOURMOHAMMADI, I., SHABANI, M., ZAVAREH, A., & MOHEBI, A.. (2006). ASSOCIATION OF VARIABLE NUMBER OF TANDEM REPEATS IN ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE WITH CORONARY ARTERY DISEASE. IRANIAN JOURNAL OF PUBLIC HEALTH, 35(4), 15-21. SID. https://sid.ir/paper/272367/en

Vancouver: Copy

SALIMI S., FIROUZRAI M., NOURMOHAMMADI I., SHABANI M., ZAVAREH A., MOHEBI A.. ASSOCIATION OF VARIABLE NUMBER OF TANDEM REPEATS IN ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE WITH CORONARY ARTERY DISEASE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2006;35(4):15-21. Available from: https://sid.ir/paper/272367/en

IEEE: Copy

S. SALIMI, M. FIROUZRAI, I. NOURMOHAMMADI, M. SHABANI, A. ZAVAREH, and A. MOHEBI, “ASSOCIATION OF VARIABLE NUMBER OF TANDEM REPEATS IN ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE WITH CORONARY ARTERY DISEASE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 35, no. 4, pp. 15–21, 2006, [Online]. Available: https://sid.ir/paper/272367/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops