SERUM LEVEL OF ADIPONECTIN AND ITS ASSOCIATION WITH INSULIN SENSITIVITY IN OVERWEIGHT DIABETIC AND NON-DIABETIC IRANIAN MEN

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GIAHI L.; JAZAYERI A.; RAHIMI A.; RAHMANI M.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Iranian Journal of Public Health Year:2008 | Volume:37 | Issue:2 Page(s): 88-92

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Title

SERUM LEVEL OF ADIPONECTIN AND ITS ASSOCIATION WITH INSULIN SENSITIVITY IN OVERWEIGHT DIABETIC AND NON-DIABETIC IRANIAN MEN

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Keywords

ADIPONECTIN

INSULIN SENSITIVITY

OVER-WEIGHT

DIABETES

IRAN

Abstract

Background: ADIPONECTIN is a protein produced exclusively by adipose tissue; the reduced level of which has been shown to be involved in a variety of obesity-related disorders, such as insulin resistance and DIABETES, in different ethnic groups.This cross-sectional study was conducted to determine ADIPONECTIN level and its association with INSULIN SENSITIVITY in 20 adult overweight type-2 diabetic and 20 healthy OVER-WEIGHT non-diabetic IRANian men for the first time.Methods: Body fat mass (Bio-electric impedance), serum level of ADIPONECTIN (ELISA), fasting blood sugar and fasting insulin were measured. INSULIN SENSITIVITY was calculated using QUICKI.Results: As expected, the mean ADIPONECTIN concentration was lower in diabetics (7.7±3 mg/ml) than non-diabetics (8.1±2 mg/ml); however, the difference did not achieve statistical significance (P= 0.5). ADIPONECTIN negatively correlated with fat mass. This correlation was stronger in diabetics with a higher fat mass (r= -0.3 in diabetics vs. r= -0.01 in non-diabetics; p: N.S.). ADIPONECTIN positively related with INSULIN SENSITIVITY in both groups, although this relation was only statistically significant in non-diabetics (r= +0.5; P= 0.04). The relation between INSULIN SENSITIVITY and mean of ADIPONECTIN level was marginally significant even after adjustment for group (diabetic and non-diabetic), age and fat mass.Conclusion: Our findings are consistent with the studies on different ethnic groups which have indicated lower ADIPONECTIN levels in diabetics. Also our results confirm the relationship between a low ADIPONECTIN level and INSULIN SENSITIVITY reported in earlier studies.

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APA: Copy

GIAHI, L., JAZAYERI, A., RAHIMI, A., RAHMANI, M., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2008). SERUM LEVEL OF ADIPONECTIN AND ITS ASSOCIATION WITH INSULIN SENSITIVITY IN OVERWEIGHT DIABETIC AND NON-DIABETIC IRANIAN MEN. IRANIAN JOURNAL OF PUBLIC HEALTH, 37(2), 88-92. SID. https://sid.ir/paper/272496/en

Vancouver: Copy

GIAHI L., JAZAYERI A., RAHIMI A., RAHMANI M., ARDESHIR LARIJANI MOHAMMAD BAGHER. SERUM LEVEL OF ADIPONECTIN AND ITS ASSOCIATION WITH INSULIN SENSITIVITY IN OVERWEIGHT DIABETIC AND NON-DIABETIC IRANIAN MEN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2008;37(2):88-92. Available from: https://sid.ir/paper/272496/en

IEEE: Copy

L. GIAHI, A. JAZAYERI, A. RAHIMI, M. RAHMANI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “SERUM LEVEL OF ADIPONECTIN AND ITS ASSOCIATION WITH INSULIN SENSITIVITY IN OVERWEIGHT DIABETIC AND NON-DIABETIC IRANIAN MEN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 37, no. 2, pp. 88–92, 2008, [Online]. Available: https://sid.ir/paper/272496/en

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