NO EVIDENCE FOR ASSOCIATION BETWEEN AMELOGENESIS IMPERFECTA AND CANDIDATE GENES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHANDEHARI MOTLAGH M.; BAHMANIPOUR M.; AREF P.; POURHASHEMI S.J.; SHAHRABI M.; NAZARIAN A.R.; RAOUFIAN R.; MAHBOUBINEZHAD F.; HEYDARI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2009 | Volume:38 | Issue:1 Page(s): 4-9

Download Full-Text

View:

327

Download:

298

Cites:

Information Journal Paper

Title

NO EVIDENCE FOR ASSOCIATION BETWEEN AMELOGENESIS IMPERFECTA AND CANDIDATE GENES

Author(s)

Keywords

AMELOGENESIS IMPERFECTA

KLK4

POLYMORPHISM

CONSANGUINEOUS MARRIAGES

Abstract

Background: AMELOGENESIS IMPERFECTA (AI) is an inherited tooth disorder. Despite the fact that up to now, several gene mutations in MMP20, ENAM, AMELX and KLK4 genes have been reported to be associated with AI, many other genes suggested to be involved. The main objective of this study was to find the mutations in three major candidate genes including MMP20, ENAM and KLK4 responsible for AI from three Iranian families with generalised hypoplastic phenotype in all teeth. Methods: All exon/intron boundaries of subjected genes were amplified by polymerase chain reaction and subjected to direct sequencing. Results: One POLYMORPHISMs was identified in KLK4 exon 2, in one family a homozygous mutation was found in the third base of codon 22 for serine (TCG>TCT), but not in other families. Although these base substitutions have been occurred in the signaling domain, they do not seem to influence the activity of KLK4 protein. Conclusion: Our results might support the further evidence for genetic heterogeneity; at least, in some AI cases are not caused by a gene in these reported candidate genes.

Cites

No record.

References

No record.

Cite

APA: Copy

GHANDEHARI MOTLAGH, M., BAHMANIPOUR, M., AREF, P., POURHASHEMI, S.J., SHAHRABI, M., NAZARIAN, A.R., RAOUFIAN, R., MAHBOUBINEZHAD, F., & HEYDARI, M.. (2009). NO EVIDENCE FOR ASSOCIATION BETWEEN AMELOGENESIS IMPERFECTA AND CANDIDATE GENES. IRANIAN JOURNAL OF PUBLIC HEALTH, 38(1), 4-9. SID. https://sid.ir/paper/272558/en

Vancouver: Copy

GHANDEHARI MOTLAGH M., BAHMANIPOUR M., AREF P., POURHASHEMI S.J., SHAHRABI M., NAZARIAN A.R., RAOUFIAN R., MAHBOUBINEZHAD F., HEYDARI M.. NO EVIDENCE FOR ASSOCIATION BETWEEN AMELOGENESIS IMPERFECTA AND CANDIDATE GENES. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2009;38(1):4-9. Available from: https://sid.ir/paper/272558/en

IEEE: Copy

M. GHANDEHARI MOTLAGH, M. BAHMANIPOUR, P. AREF, S.J. POURHASHEMI, M. SHAHRABI, A.R. NAZARIAN, R. RAOUFIAN, F. MAHBOUBINEZHAD, and M. HEYDARI, “NO EVIDENCE FOR ASSOCIATION BETWEEN AMELOGENESIS IMPERFECTA AND CANDIDATE GENES,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 38, no. 1, pp. 4–9, 2009, [Online]. Available: https://sid.ir/paper/272558/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops