CO-INHERITANCE OF SICKLE CELL TRAIT AND THALASSEMIA MUTATIONS IN SOUTH CENTRAL IRAN

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SALEH GOHARI N.; MOHAMMADI ANAIE M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Public Health Year:2012 | Volume:41 | Issue:10 Page(s): 81-86

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Information Journal Paper

Title

CO-INHERITANCE OF SICKLE CELL TRAIT AND THALASSEMIA MUTATIONS IN SOUTH CENTRAL IRAN

Author(s)

SALEH GOHARI N. | MOHAMMADI ANAIE M. | Issue Writer Certificate

Keywords

SICKLE CELL TRAIT

β-THALASSEMIA

α-THALASSEMIA

IRAN

Abstract

Background: We aimed to determine the incidence of co-inheritance as well as interaction of SICKLE CELL TRAIT (SCT) and athal/bthal mutations in south and south central of IRAN.Method: We employed a PCR and restriction fragment length polymorphism techniques to confirm diagnosis of SICKLE CELL TRAIT. All subjects were screened for any a/b –thalassemia mutations using a gap-polymerase chain reaction and amplification refractory mutations system.Results: Our results showed combination of SICKLE CELL TRAIT and b-globin mutation results in a severe clinical course of similar to sickle cell disease, while coinheritance of a-globin gene defects usually modulates the clinical course. A coexistence of SICKLE CELL TRAIT and a-globin gene mutation was the frequent genotype in overall samples (57.5%).Conclusion: SICKLE CELL TRAIT mainly co-inherits with a-globin gene mutation in the south and south central region of IRAN. This combination modulates hematological indices and interferes with the SCT diagnosis.

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APA: Copy

SALEH GOHARI, N., & MOHAMMADI ANAIE, M.. (2012). CO-INHERITANCE OF SICKLE CELL TRAIT AND THALASSEMIA MUTATIONS IN SOUTH CENTRAL IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH, 41(10), 81-86. SID. https://sid.ir/paper/272982/en

Vancouver: Copy

SALEH GOHARI N., MOHAMMADI ANAIE M.. CO-INHERITANCE OF SICKLE CELL TRAIT AND THALASSEMIA MUTATIONS IN SOUTH CENTRAL IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2012;41(10):81-86. Available from: https://sid.ir/paper/272982/en

IEEE: Copy

N. SALEH GOHARI, and M. MOHAMMADI ANAIE, “CO-INHERITANCE OF SICKLE CELL TRAIT AND THALASSEMIA MUTATIONS IN SOUTH CENTRAL IRAN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 41, no. 10, pp. 81–86, 2012, [Online]. Available: https://sid.ir/paper/272982/en

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