DO BIOCHEMICAL MARKERS AND APA I POLYMORPHISM IN IGF-II GENE PLAY A ROLE IN THE ASSOCIATION OF BIRTH WEIGHT AND LATER BMI?

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WU JUNQING; REN JINGCHAO; LI YUYAN; WU YINJIE; GAO ERSHENG

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Journal: Iranian Journal of Public Health Year:2013 | Volume:42 | Issue:5 Page(s): 480-488

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Title

DO BIOCHEMICAL MARKERS AND APA I POLYMORPHISM IN IGF-II GENE PLAY A ROLE IN THE ASSOCIATION OF BIRTH WEIGHT AND LATER BMI?

Author(s)

Keywords

BIOCHEMICAL MARKER

APA I POLYMORPHISM

BIRTH WEIGHT

BMI

IGF-II GENE

Abstract

Background: The aim of the study was to explore the mechanisms underlying the association of BIRTH WEIGHT with later body mass index (BMI) from the BIOCHEMICAL MARKERs related to metabolism and the APA I POLYMORPHISM in IGF-II GENE.Methods: A total of 300 children were selected randomly from the Macrosomia Birth Cohort in Wuxi, China. The height and weight were measured and blood samples were collected. Plasma concentrations of 8 BIOCHEMICAL MARKERs were detected. APA I POLYMORPHISM was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: BIOCHEMICAL MARKERs were detected for 296 subjects and 271 subjects were genotyped for the APA I POLYMORPHISM. No association was found between BIRTH WEIGHT and 8 BIOCHEMICAL MARKERs. In boys, the BMIs of AA, AG and GG genotypes were 16.10±2.24 kg/m2, 17.40±3.20 kg/m2, 17.65±2.66 kg/m2. And there was statistical difference among the three genotypes. But in girls, there was no statistical difference. The BIRTH WEIGHTs of AA, AG and GG genotypes were 3751.13±492.43 g, 3734.00±456.88 g, 3782.00±461.78 g. And there was no statistical difference among the three genotypes.Conclusion: BIOCHEMICAL MARKERs are not associated with BIRTH WEIGHT. APA I POLYMORPHISM may be related to child-hood BMI, but it may be not associated with BIRTH WEIGHT. Therefore, BIOCHEMICAL MARKERs and APA I POLYMORPHISM might not play a role in the association of BIRTH WEIGHT and BMI.

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APA: Copy

WU, JUNQING, REN, JINGCHAO, LI, YUYAN, WU, YINJIE, & GAO, ERSHENG. (2013). DO BIOCHEMICAL MARKERS AND APA I POLYMORPHISM IN IGF-II GENE PLAY A ROLE IN THE ASSOCIATION OF BIRTH WEIGHT AND LATER BMI?. IRANIAN JOURNAL OF PUBLIC HEALTH, 42(5), 480-488. SID. https://sid.ir/paper/273108/en

Vancouver: Copy

WU JUNQING, REN JINGCHAO, LI YUYAN, WU YINJIE, GAO ERSHENG. DO BIOCHEMICAL MARKERS AND APA I POLYMORPHISM IN IGF-II GENE PLAY A ROLE IN THE ASSOCIATION OF BIRTH WEIGHT AND LATER BMI?. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2013;42(5):480-488. Available from: https://sid.ir/paper/273108/en

IEEE: Copy

JUNQING WU, JINGCHAO REN, YUYAN LI, YINJIE WU, and ERSHENG GAO, “DO BIOCHEMICAL MARKERS AND APA I POLYMORPHISM IN IGF-II GENE PLAY A ROLE IN THE ASSOCIATION OF BIRTH WEIGHT AND LATER BMI?,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 42, no. 5, pp. 480–488, 2013, [Online]. Available: https://sid.ir/paper/273108/en

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