EFFECT OF ADMINISTRATION OF DIFFERENT DOSES OF STREPTOZOTOCIN RENAL MORPHOMETRIC PARAMETERS IN RATS

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HEIDARI Z.; MAHMOUDZADEH SAGHEB H.R.; NOURI MOUGEHI S.M.H.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2003 | Volume:5 | Issue:3 (SN 19) Page(s): 165-172

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Title

EFFECT OF ADMINISTRATION OF DIFFERENT DOSES OF STREPTOZOTOCIN RENAL MORPHOMETRIC PARAMETERS IN RATS

Author(s)

HEIDARI Z. | MAHMOUDZADEH SAGHEB H.R. | NOURI MOUGEHI S.M.H. | Issue Writer Certificate

Keywords

DIABETESQ3

STREPTOZOTOCINQ2

KIDNEYQ2

GLOMERULIQ4

MORPHOMETRYQ3

Abstract

Introduction: Due to the relationship between structure and function, the study of glomerular volume is important to understand initiation and progression of diabetic glomerulopathy. The aims of the present study were to estimate renal volume as well as absolute glomerular volume and total glomerular number in diabetic rats following administration of different doses of STREPTOZOTOCIN (STZ), by using unbiased morphometric methods. Material and Methods: Male Wistar rats with an average weight of 110 gr were randomly divided into 5 groups. DIABETES was induced by an IP injection of Stereptozotocin 15mg/kg, 45mg/kg and 90 mg/kg. Fifty-six days after IP injection, the animals were anesthetized by ketamine hydrochloride and the KIDNEYs were excised, decapsulated and fixed in modified Lilli(s) solution. After tissue processing and staining, new morphometric methods were used to estimate the volumes of different zones of KIDNEY, absolute glomerular volume and total glomerular number. Results: This experiment showed increased cortical tissue volume in all groups whereas medullary volume increased only in the group which received 90mg/kg of STZ (P<0.01). Glomerular volume was increased significantly in all groups (P<0.01) but no changes in total glomerular number were detected (P>0.05). Conclusion: This study revealed that, at least, after short periods of inducing DIABETES mellitus, administration of more STZ might have more effects on KIDNEYs and cause more imbalances in cells turnover.

Cites

EFFECT OF BARLEY GRAIN (HORDEUM VULGARE L.) CONSUMPTION DURING PREGNANCY IN INDUCED DIABETIC RATS ON KIDNEY HISTOLOGICAL ALTRATIONS OF OFFSPRINGS

References

EVALUATION OF RENAL GLOMERULI NUMBER CHANGES IN MALE DIABETIC RATS BY USING STEREOLOGICAL METHODS

Cite

APA: Copy

HEIDARI, Z., MAHMOUDZADEH SAGHEB, H.R., & NOURI MOUGEHI, S.M.H.. (2003). EFFECT OF ADMINISTRATION OF DIFFERENT DOSES OF STREPTOZOTOCIN RENAL MORPHOMETRIC PARAMETERS IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 5(3 (SN 19)), 165-172. SID. https://sid.ir/paper/27317/en

Vancouver: Copy

HEIDARI Z., MAHMOUDZADEH SAGHEB H.R., NOURI MOUGEHI S.M.H.. EFFECT OF ADMINISTRATION OF DIFFERENT DOSES OF STREPTOZOTOCIN RENAL MORPHOMETRIC PARAMETERS IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2003;5(3 (SN 19)):165-172. Available from: https://sid.ir/paper/27317/en

IEEE: Copy

Z. HEIDARI, H.R. MAHMOUDZADEH SAGHEB, and S.M.H. NOURI MOUGEHI, “EFFECT OF ADMINISTRATION OF DIFFERENT DOSES OF STREPTOZOTOCIN RENAL MORPHOMETRIC PARAMETERS IN RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 5, no. 3 (SN 19), pp. 165–172, 2003, [Online]. Available: https://sid.ir/paper/27317/en

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