METALLOTHIONEIN LOWER UNDER-EXPRESSION IN BENIGN TUMORS THAN THAT IN MALIGNANT TUMORS: SYSTEMATIC REVIEW ARTICLE AND META-ANALYSIS

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ZHANG JIE; SUN RUIJIE; LIU YUE; WANG GUINIAN; WANG QINGLU

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Public Health Year:2014 | Volume:43 | Issue:6 Page(s): 696-704

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Title

METALLOTHIONEIN LOWER UNDER-EXPRESSION IN BENIGN TUMORS THAN THAT IN MALIGNANT TUMORS: SYSTEMATIC REVIEW ARTICLE AND META-ANALYSIS

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Keywords

METALLOTHIONEIN

BENIGN TUMORS

MALIGNANT TUMORS

META-ANALYSIS

Abstract

Background: METALLOTHIONEIN (MT) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A META-ANALYSIS was conducted to evaluate comprehensively the MT expression difference in various BENIGN TUMORS and MALIGNANT TUMORS, which compared the high with low MT expression levels in patients of the available studies. Finally, a total of 13 studies dealing with various tumors were involved for this META-ANALYSIS. The results indicated that lower expression of MT in various BENIGN TUMORS tissue than that in corresponding MALIGNANT TUMORS with the pooled OR of 0.52 (95% CI 0.18-1.47, P<0.001). In conclusion, MT expression difference is associated with tumor various stages in tumor patients and could be a useful clinical criteria of distinguishing BENIGN TUMORS and MALIGNANT TUMORS for those patients.

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APA: Copy

ZHANG, JIE, SUN, RUIJIE, LIU, YUE, WANG, GUINIAN, & WANG, QINGLU. (2014). METALLOTHIONEIN LOWER UNDER-EXPRESSION IN BENIGN TUMORS THAN THAT IN MALIGNANT TUMORS: SYSTEMATIC REVIEW ARTICLE AND META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(6), 696-704. SID. https://sid.ir/paper/273256/en

Vancouver: Copy

ZHANG JIE, SUN RUIJIE, LIU YUE, WANG GUINIAN, WANG QINGLU. METALLOTHIONEIN LOWER UNDER-EXPRESSION IN BENIGN TUMORS THAN THAT IN MALIGNANT TUMORS: SYSTEMATIC REVIEW ARTICLE AND META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2014;43(6):696-704. Available from: https://sid.ir/paper/273256/en

IEEE: Copy

JIE ZHANG, RUIJIE SUN, YUE LIU, GUINIAN WANG, and QINGLU WANG, “METALLOTHIONEIN LOWER UNDER-EXPRESSION IN BENIGN TUMORS THAN THAT IN MALIGNANT TUMORS: SYSTEMATIC REVIEW ARTICLE AND META-ANALYSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 43, no. 6, pp. 696–704, 2014, [Online]. Available: https://sid.ir/paper/273256/en

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