ANALYSIS OF MTHFR GENE C.677C>T AND C.1298A>C POLYMORPHISMS IN IRANIAN PATIENTS WITH NON-SYNDROMIC CLEFT LIP AND PALATE

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JAHANBIN AREZOO; HASANZADEH NADIA; ABDOLHOSEINPOUR FARANEH; SADR NABAVI ARIANE; RAISOLSADAT MOHAMMAD ALI; SHAMSIAN KHOSRO; MOHAJERTEHRAN FARNAZ; KIANIFAR HAMIDREZA

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Journal: Iranian Journal of Public Health Year:2014 | Volume:43 | Issue:6 Page(s): 821-827

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Title

ANALYSIS OF MTHFR GENE C.677C>T AND C.1298A>C POLYMORPHISMS IN IRANIAN PATIENTS WITH NON-SYNDROMIC CLEFT LIP AND PALATE

Author(s)

Keywords

MTHFR

FOLIC ACID

METHYLENETETRAHYDROFOLATE REDUCTASE

CLEFT LIP

CLEFT PALATE

NON-SYNDROMIC CLEFT

Abstract

Background: Non-syndromic CLEFT LIP with or without CLEFT PALATE (nsCL/P) is one of the most common congenital abnormalities of the orofacial region with a multifactorial etiology. The present study aimed to investigate the association of two common polymorphisms of METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) gene (c.677C>T and c.1298A>C) with the occurrence of nsCL/P in an Iranian population.Methods: Forty-five nsCL/P patients, 43 mothers of patients, and 101 unrelated controls participated in the present study. Analysis of c.677C>T and c.1298A>C polymorphisms in MTHFR gene was conducted using polymerase chain reaction and restriction enzyme digestions.Results: There was no statistical difference in genotype and allele frequencies for c.677C>T variants between patients or their mothers and the control group. However, differences in the frequencies of alleles and genotypes of c.1298A>C polymorphism were statistically significant between patients and control group (P=0.01 for alleles and P=0.005 for genotypes). The odds ratios (OR) for the CC versus AA homozygotes were 6.1 (95% CI 1.8-20.5) and 4.2 (95% CI 1.1-15.4), in patients and mothers, respectively.Conclusions: We found no association between genetic polymorphism of MTHFR c.677C>T and the risk of nsCL/P in the population studied. Yet the results suggested that c.1298A>C polymorphism of MTHFR gene may be a risk factor for the occurrence of nsCL/P in the Iranian population.

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APA: Copy

JAHANBIN, AREZOO, HASANZADEH, NADIA, ABDOLHOSEINPOUR, FARANEH, SADR NABAVI, ARIANE, RAISOLSADAT, MOHAMMAD ALI, SHAMSIAN, KHOSRO, MOHAJERTEHRAN, FARNAZ, & KIANIFAR, HAMIDREZA. (2014). ANALYSIS OF MTHFR GENE C.677C>T AND C.1298A>C POLYMORPHISMS IN IRANIAN PATIENTS WITH NON-SYNDROMIC CLEFT LIP AND PALATE. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(6), 821-827. SID. https://sid.ir/paper/273258/en

Vancouver: Copy

JAHANBIN AREZOO, HASANZADEH NADIA, ABDOLHOSEINPOUR FARANEH, SADR NABAVI ARIANE, RAISOLSADAT MOHAMMAD ALI, SHAMSIAN KHOSRO, MOHAJERTEHRAN FARNAZ, KIANIFAR HAMIDREZA. ANALYSIS OF MTHFR GENE C.677C>T AND C.1298A>C POLYMORPHISMS IN IRANIAN PATIENTS WITH NON-SYNDROMIC CLEFT LIP AND PALATE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2014;43(6):821-827. Available from: https://sid.ir/paper/273258/en

IEEE: Copy

AREZOO JAHANBIN, NADIA HASANZADEH, FARANEH ABDOLHOSEINPOUR, ARIANE SADR NABAVI, MOHAMMAD ALI RAISOLSADAT, KHOSRO SHAMSIAN, FARNAZ MOHAJERTEHRAN, and HAMIDREZA KIANIFAR, “ANALYSIS OF MTHFR GENE C.677C>T AND C.1298A>C POLYMORPHISMS IN IRANIAN PATIENTS WITH NON-SYNDROMIC CLEFT LIP AND PALATE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 43, no. 6, pp. 821–827, 2014, [Online]. Available: https://sid.ir/paper/273258/en

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