THE EFFECT OF BODY COMPOSITION AND PHYSICAL ACTIVITY ON BASAL LEVELS OF INSULIN, GLUCOSE, IL-18, IL-6 & CRP AND THEIR RELATIONSHIP WITH INSULIN RESISTANCE

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AMANI SHALAMZADI S.; AGHA ALINEZHAD HAMID; GHARAKHANLOU R.; MOLA NOURI SHAMSI MAHDIEH; TALEBI BADRABADI K.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2010 | Volume:11 | Issue:6 (SN 48) Page(s): 699-706

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Title

THE EFFECT OF BODY COMPOSITION AND PHYSICAL ACTIVITY ON BASAL LEVELS OF INSULIN, GLUCOSE, IL-18, IL-6 & CRP AND THEIR RELATIONSHIP WITH INSULIN RESISTANCE

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Keywords

OBESITYQ2

INSULIN RESISTANCEQ2

LEVELS OF EXERCISEQ3

INFLAMMATORY MARKERSQ3

Abstract

Introduction: OBESITY and physically inactive lifestyles are associated with an increased risk for developing INSULIN RESISTANCE. It has been confirmed that INSULIN RESISTANCE is a common feature in many inflammatory diseases and can be recognized with overproduced levels of markers such as IL-6, IL-18 & CRP. The aim of this study was to determine whether OBESITY or inactivity is stronger factors in the developmental INSULIN RESISTANCE, considering INSULIN RESISTANCE markers such as IL-6, IL-18 and CRP.Materials and Methods: Thirty-two healthy, male students participated in the present study, age 24.8±2.52 years, height 175.47±6.7, and weight 81.64±20.14). Weight and body fat were measured with the body composition set and LEVELS OF EXERCISE was determined with the PA-Rscore questionnaire. All subjects based on body fat and LEVELS OF EXERCISE were divided into 4 groups: Active obese (n=8), active, non-obese (n=8), inactive, obese (n=8) and inactive, nonobese (n=8). To determine fasting values of IL-6, IL-18, CRP, glucose and insulin blood samples were obtained at 8 a.m.Results: Obese subjects had higher resting levels of IL-6, IL18, CRP and insulin than lean subjects, with no significant difference between active lean and inactive lean subjects at resting levels of INFLAMMATORY MARKERS. However there was a significant difference in the resting levels of IL-18 between active and inactive obese subjects (t=-2.51 P=0.031), and also a significant difference in resting levels of IL-6, IL-18, CRP, insulin and HOMA between inactive obese with active and inactive lean subjects, IL-18 having the strongest relationship with HOMA (r=0. 54 p=0.001).Conclusion: Results indicated that OBESITY is a stronger factor than inactivity for development of INSULIN RESISTANCE. On the other hand, activity has anti-inflammatory effects, and hence can decrease the effects of OBESITY, in the development of INSULIN RESISTANCE.

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APA: Copy

AMANI SHALAMZADI, S., AGHA ALINEZHAD, HAMID, GHARAKHANLOU, R., MOLA NOURI SHAMSI, MAHDIEH, & TALEBI BADRABADI, K.. (2010). THE EFFECT OF BODY COMPOSITION AND PHYSICAL ACTIVITY ON BASAL LEVELS OF INSULIN, GLUCOSE, IL-18, IL-6 & CRP AND THEIR RELATIONSHIP WITH INSULIN RESISTANCE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 11(6 (SN 48)), 699-706. SID. https://sid.ir/paper/27363/en

Vancouver: Copy

AMANI SHALAMZADI S., AGHA ALINEZHAD HAMID, GHARAKHANLOU R., MOLA NOURI SHAMSI MAHDIEH, TALEBI BADRABADI K.. THE EFFECT OF BODY COMPOSITION AND PHYSICAL ACTIVITY ON BASAL LEVELS OF INSULIN, GLUCOSE, IL-18, IL-6 & CRP AND THEIR RELATIONSHIP WITH INSULIN RESISTANCE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2010;11(6 (SN 48)):699-706. Available from: https://sid.ir/paper/27363/en

IEEE: Copy

S. AMANI SHALAMZADI, HAMID AGHA ALINEZHAD, R. GHARAKHANLOU, MAHDIEH MOLA NOURI SHAMSI, and K. TALEBI BADRABADI, “THE EFFECT OF BODY COMPOSITION AND PHYSICAL ACTIVITY ON BASAL LEVELS OF INSULIN, GLUCOSE, IL-18, IL-6 & CRP AND THEIR RELATIONSHIP WITH INSULIN RESISTANCE,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 11, no. 6 (SN 48), pp. 699–706, 2010, [Online]. Available: https://sid.ir/paper/27363/en

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