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Information Journal Paper

Title

EFFECT OF VITAMIN E AND METFORMIN ON FATTY LIVER DISEASE IN OBESE CHILDREN- RANDOMIZED CLINICAL TRIAL

Pages

  1417-1423

Abstract

 Background: We evaluated the effect of VITAMIN E and METFORMIN on FATTY LIVER DISEASE in obese CHILDREN.Methods: This interventional study has been done on 119 CHILDREN with Non-alcoholic FATTY LIVER DISEASE (based on sonography results). Patients were divided into four treatment groups; they received METFORMIN 1gr daily (age<12 years), METFORMIN 1.5 gr daily (age>12 years), VITAMIN E 800 U daily and VITAMIN E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials (IRCT), No.IRCT2013021012421N1 Results: The study group comprised 119 individuals (62 females, 57 males). The mean age was 10 ± 3.19 yr. There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients (55.46%), 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received VITAMIN E 800 u daily (48.1%) and the least therapeutic response was in the group which received VITAMIN E 400 u daily (14.3%). After four months, the greater response was seen in VITAMIN E 400 u daily group (45.8%) and the least response in the METFORMIN 1 gram daily group (19%).Conclusion: In comparison with METFORMIN, VITAMIN E is more influential in remission; however both are efficient in treatment of fatty liver. VITAMIN E 400 u daily responses better in four-month treatment.

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    APA: Copy

    SHIASI ARANI, KOBRA, TAGHAVI ARDAKANI, ABBAS, MOAZAMI GOUDARZI, RAZIEH, TALARI, HAMID REZA, ADHAMI, KAMRAN, HAMI, KAMRAN, AKBARI, HOSSEIN, & AKBARI, NIMA. (2014). EFFECT OF VITAMIN E AND METFORMIN ON FATTY LIVER DISEASE IN OBESE CHILDREN- RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(10), 1417-1423. SID. https://sid.ir/paper/273670/en

    Vancouver: Copy

    SHIASI ARANI KOBRA, TAGHAVI ARDAKANI ABBAS, MOAZAMI GOUDARZI RAZIEH, TALARI HAMID REZA, ADHAMI KAMRAN, HAMI KAMRAN, AKBARI HOSSEIN, AKBARI NIMA. EFFECT OF VITAMIN E AND METFORMIN ON FATTY LIVER DISEASE IN OBESE CHILDREN- RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2014;43(10):1417-1423. Available from: https://sid.ir/paper/273670/en

    IEEE: Copy

    KOBRA SHIASI ARANI, ABBAS TAGHAVI ARDAKANI, RAZIEH MOAZAMI GOUDARZI, HAMID REZA TALARI, KAMRAN ADHAMI, KAMRAN HAMI, HOSSEIN AKBARI, and NIMA AKBARI, “EFFECT OF VITAMIN E AND METFORMIN ON FATTY LIVER DISEASE IN OBESE CHILDREN- RANDOMIZED CLINICAL TRIAL,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 43, no. 10, pp. 1417–1423, 2014, [Online]. Available: https://sid.ir/paper/273670/en

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