ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE -1562C/T POLYMORPHISM WITH ESSENTIAL HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS ARTICLE

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YANG WENCHAO; LU JIAOJIAO; YANG LIU; ZHANG JINJIN

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Journal Paper

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Journal: Iranian Journal of Public Health Year:2015 | Volume:44 | Issue:11 Page(s): 1445-1452

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Title

ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE -1562C/T POLYMORPHISM WITH ESSENTIAL HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS ARTICLE

Author(s)

YANG WENCHAO | LU JIAOJIAO | YANG LIU | ZHANG JINJIN | Issue Writer Certificate

Keywords

MMP-9

ESSENTIAL HYPERTENSION

META-ANALYSIS

Abstract

Background: Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people’s predisposition to ESSENTIAL HYPERTENSION. However, related studies yielded inconsistent or contradictory results.Methods: To evaluate the association of MMP-9 -1562C/T polymorphism with ESSENTIAL HYPERTENSION, we performed a META-ANALYSIS by combining all available independent case-control studies (n=6).A systematic literature search of PubMed, Web of Science, Scopus and CNKI (Chinese National Knowledge Infrastructure) databases was conducted by two researchers independently for all relevant articles published before March 2015.Results: MMP-9 -1562C/T polymorphism was associated with ESSENTIAL HYPERTENSION under the allelic model (T vs.C, OR=1.36, 95% CI=1.17-1.59, P<0.0001). Subsequent sensitivity analysis confirmed the stability of the results. Such association was also observed in the dominant (TT+CT vs. CC, OR=1.30, 95% CI=1.10-1.54, P=0.002) and co-dominant (CT vs. TT+CC, OR=1.27, 95% CI=1.05-1.53, P=0.01) models but not in the recessive model (TT vs. CT+CC, OR=1.30, 95% CI=0.50-3.36, P=0.59).Conclusion: MMP-9 -1562C/T polymorphism was associated with the risk of ESSENTIAL HYPERTENSION.

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APA: Copy

YANG, WENCHAO, LU, JIAOJIAO, YANG, LIU, & ZHANG, JINJIN. (2015). ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE -1562C/T POLYMORPHISM WITH ESSENTIAL HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS ARTICLE. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(11), 1445-1452. SID. https://sid.ir/paper/273782/en

Vancouver: Copy

YANG WENCHAO, LU JIAOJIAO, YANG LIU, ZHANG JINJIN. ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE -1562C/T POLYMORPHISM WITH ESSENTIAL HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS ARTICLE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(11):1445-1452. Available from: https://sid.ir/paper/273782/en

IEEE: Copy

WENCHAO YANG, JIAOJIAO LU, LIU YANG, and JINJIN ZHANG, “ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE -1562C/T POLYMORPHISM WITH ESSENTIAL HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS ARTICLE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 11, pp. 1445–1452, 2015, [Online]. Available: https://sid.ir/paper/273782/en

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