مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF GENISTEIN AND L-CARNITINE AND THEIR COMBINATION ON GENE EXPRESSION OF HEPATOCYTE HMG-COA REDUCTASE AND LDL RECEPTOR IN EXPERIMENTAL NEPHROTIC SYNDROME

Pages

  1339-1347

Abstract

 Background: NEPHROTIC SYNDROME is a disorder that leads to hyperlipidemia. L-CARNITINE and GENISTEIN can effect on lipid metabolism and the syndrome. In the present study, we have delved into the separate and the twin-effects of L-CARNITINE and GENISTEIN on the GENE expressions of HMG-COA reductase and LDL RECEPTOR in experimental NEPHROTIC SYNDROME.Methods: In this controlled experimental study, 50 male Sprague–Dawley rats were randomly divided into five groups: NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), LCG (L-carnitine-genistein). Adri-amycin was used for inducing NEPHROTIC SYNDROME and the spot urine samples and urine protein-to-creatinine ratio were measured. Hepatocytic RNA was extracted and real-time PCR was used for HMG-COA Reductase and LDL RECEPTOR GENE Expression measurement.Results: The final weight of the patients groups were lower than the NC group (P=0.001), and weight gain of the NC group was higher than the other groups (P<0.001). The proteinuria and urine protein-to-creatinine ratio showed sig-nificant differences between PC group and LC, G and LCG groups at week 7 (P<0.001). The expression of HMG-COA Reductase mRNA down regulated in LC, G and LCG groups in comparison with PC group (P<0.001). ΔCT of LDLr mRNA showed significant differences between the PC group and the other patient groups (P<0.001).Conclusion: This study shows a significant decreasing (P<0.001) and non-significant increasing trend in HMG-COA Reductase and LDLr GENE expression, respectively, and synergistic effect of L-CARNITINE and GENISTEIN on these GENEs in experimental NEPHROTIC SYNDROME.

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    Cite

    APA: Copy

    YOUSEFINEJAD, ABBAS, SIASSI, FEREYDOON, MIRSHAFIEY, ABBAS, ESHRAGHIAN, MOHAMMADREZA, KOOHDANI, FARIBA, JAVANBAKHT, MOHAMMAD HASSAN, SEDAGHAT, REZA, RAMEZANI, ATENA, ZAREI, MAHNAZ, & DJALALI, MAHMOUD. (2015). EFFECT OF GENISTEIN AND L-CARNITINE AND THEIR COMBINATION ON GENE EXPRESSION OF HEPATOCYTE HMG-COA REDUCTASE AND LDL RECEPTOR IN EXPERIMENTAL NEPHROTIC SYNDROME. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(10), 1339-1347. SID. https://sid.ir/paper/273815/en

    Vancouver: Copy

    YOUSEFINEJAD ABBAS, SIASSI FEREYDOON, MIRSHAFIEY ABBAS, ESHRAGHIAN MOHAMMADREZA, KOOHDANI FARIBA, JAVANBAKHT MOHAMMAD HASSAN, SEDAGHAT REZA, RAMEZANI ATENA, ZAREI MAHNAZ, DJALALI MAHMOUD. EFFECT OF GENISTEIN AND L-CARNITINE AND THEIR COMBINATION ON GENE EXPRESSION OF HEPATOCYTE HMG-COA REDUCTASE AND LDL RECEPTOR IN EXPERIMENTAL NEPHROTIC SYNDROME. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(10):1339-1347. Available from: https://sid.ir/paper/273815/en

    IEEE: Copy

    ABBAS YOUSEFINEJAD, FEREYDOON SIASSI, ABBAS MIRSHAFIEY, MOHAMMADREZA ESHRAGHIAN, FARIBA KOOHDANI, MOHAMMAD HASSAN JAVANBAKHT, REZA SEDAGHAT, ATENA RAMEZANI, MAHNAZ ZAREI, and MAHMOUD DJALALI, “EFFECT OF GENISTEIN AND L-CARNITINE AND THEIR COMBINATION ON GENE EXPRESSION OF HEPATOCYTE HMG-COA REDUCTASE AND LDL RECEPTOR IN EXPERIMENTAL NEPHROTIC SYNDROME,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 10, pp. 1339–1347, 2015, [Online]. Available: https://sid.ir/paper/273815/en

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