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Information Journal Paper

Title

THE ASSOCIATION BETWEEN PTPN22 GENETIC POLYMORPHISM AND JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUSCEPTIBILITY: AN UPDATED META-ANALYSIS

Pages

  1169-1175

Abstract

 Background: Limited studies have focused on the association between the protein tyrosine PHOSPHATES NON-RECEPTOR TYPE 22 (PTPN22) genetic POLYMORPHISMs and JUVENILE IDIOPATHIC ARTHRITIS (JIA) susceptibility in different populations, but the results were inconclusive. Therefore, this META-ANALYSIS of PTPN22 POLYMORPHISM (1858 C＞T) was per-formed to get a precise systematic estimation. The "rs" number of the PTPN22 POLYMORPHISM (1858 C＞T) is 4.Methods: A systematic literature search strategy was carried out using English databases (PubMed, Embase.) for the eligible studies. We ultimately identified 11 records from 10 articles involving the relationship between PTPN22 genet-ic POLYMORPHISMs and JIA risk from PubMed and Embase databases. Overall, 4552 cases and 10161 controls were investigated in this study to evaluate the association between PTPN22 (C allele vs. T allele) genotype and JIA suscepti-bility.Results: Analysis using random effects model showed an increased risk of JIA with T allele of rs2476601 vs. A allele (P<0.001). Subgroup analysis suggested that the PTPN22 POLYMORPHISM (1858C＞T) was significantly associated with JIA risk in America population (OR=1.52, 95%CI: 1.30-1.78). Additionally, the subgroup analysis also showed that the associations were still significant in case number more than 500 (OR=1.38, 95% CI: 1.04-1.83), while in the case num-ber less than 500 was OR=1.55, 95% CI: 1.39-1.72.Conclusions: SNPs of PTPN22 (1858C＞T) showed an increased risk of developing JIA.

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    APA: Copy

    DI, YAZHEN, ZHONG, SHILLING, WU, LING, LI, YUNYAN, & SUN, NAN. (2015). THE ASSOCIATION BETWEEN PTPN22 GENETIC POLYMORPHISM AND JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUSCEPTIBILITY: AN UPDATED META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(9), 1169-1175. SID. https://sid.ir/paper/273835/en

    Vancouver: Copy

    DI YAZHEN, ZHONG SHILLING, WU LING, LI YUNYAN, SUN NAN. THE ASSOCIATION BETWEEN PTPN22 GENETIC POLYMORPHISM AND JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUSCEPTIBILITY: AN UPDATED META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(9):1169-1175. Available from: https://sid.ir/paper/273835/en

    IEEE: Copy

    YAZHEN DI, SHILLING ZHONG, LING WU, YUNYAN LI, and NAN SUN, “THE ASSOCIATION BETWEEN PTPN22 GENETIC POLYMORPHISM AND JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUSCEPTIBILITY: AN UPDATED META-ANALYSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 9, pp. 1169–1175, 2015, [Online]. Available: https://sid.ir/paper/273835/en

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