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Information Journal Paper

Title

GENETIC OF ALZHEIMER'S DISEASE: A NARRATIVE REVIEW ARTICLE

Pages

  892-901

Keywords

ALZHEIMER'S DISEASE (AD) 
EARLY-ONSET TYPE (EOAD) 
LATE-ONSET TYPE (LOAD) 

Abstract

 Background: Alzheimer's disease (AD) is one of the most common problems for old peoples. Etiology of AD is not clear, but GENETIC FACTORS play a major role in determining a person's risk to develop AD. Twin and family studies con-firm that AD has a genetic basis.AD genetics has been split into two broad categories: early-onset and late-onset. EO-AD cases are inherited in an autosomal dominant pattern. In this form, dominant mutations in genes like APP, PSEN-1 and PSEN-2 associated with AD. This study aimed to consider the role of genetic in AD.Method: At the first, most of the references in relation with genetic basis of AD searched from the following web-sites: PubMed, Science direct, Wiley & Sons (1995-2014). Then, the most common genes and their affects described briefly.Results: Aging is the most obvious risk factor for developing AD. There is a genetic basis for AD, of course this relation is not complete but it is significant.Conclusion: More than thousand genes studied in relation with Alzheimer's disease. Against the improvements in understanding different aspects of AD, the accurate genetic foundation of AD remain unclear.

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  • Cite

    APA: Copy

    KHANAHMADI, MOHAMMAD, D.FARHUD, DARIUSH, & MALMIR, MARYAM. (2015). GENETIC OF ALZHEIMER'S DISEASE: A NARRATIVE REVIEW ARTICLE. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(7), 892-901. SID. https://sid.ir/paper/273898/en

    Vancouver: Copy

    KHANAHMADI MOHAMMAD, D.FARHUD DARIUSH, MALMIR MARYAM. GENETIC OF ALZHEIMER'S DISEASE: A NARRATIVE REVIEW ARTICLE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(7):892-901. Available from: https://sid.ir/paper/273898/en

    IEEE: Copy

    MOHAMMAD KHANAHMADI, DARIUSH D.FARHUD, and MARYAM MALMIR, “GENETIC OF ALZHEIMER'S DISEASE: A NARRATIVE REVIEW ARTICLE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 7, pp. 892–901, 2015, [Online]. Available: https://sid.ir/paper/273898/en

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