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Information Journal Paper

Title

ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN TOLL-LIKE RECEPTORS WITH ACINETOBACTER BAUMANII INFECTIONIN A CHINESE POPULATION

Pages

  20-26

Abstract

 Background: During recent years, infection of ACINETOBACTER BAUMANII showed a rapid growth in hospitals and commu-nity. TOLL-LIKE RECEPTORS (TLRs) are the most important pattern recognition receptors, which play a critical role during recognizing invading pathogens by the natural immune system. Our objective was to determine the associations of TLRs polymorphisms with the susceptibility to A. baumanii infection in a Chinese population.Methods: We carried out a case-control study, genotyping 13 polymorphisms of TLR-2, TLR-4, TLR-5 and TLR-9 genes on 423 A. baumanii-infected patients and 385 exposed controls. Thirteen SNPs at the TLR-2 (rs3804099, rs7656411 and rs76112010), TLR-4 (rs1927914, rs10759932 and rs11536889), TLR-5 (rs1341987, rs1640827, rs1861172, rs2241097, rs5744174 and rs17163737) and TLR9 (rs187084) genes were analyzed. SNP genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique.Results: The SNP of TLR-9, rs187084, was related to A. baumanii-infection significantly under recessive model (G/G, to A/A+G/A, P=0.0064, OR=0.59, 95% CI=0.40-0.86) after adjustment with age. Besides, the haplotype GCG of TLR-4 was significantly associated with A. baumanii infection (P=0.027).Conclusion: TLR-4 and TLR-9 may be related to the susceptibility to A. baumanii infection in a Chinese population.

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    APA: Copy

    AMOURACHE, LEILA, LIN, MAOHU, FAN, WENSHENG, LIU, YUNXI, SUO, JIJIANG, XING, YUBIN, & JIA, NING. (2016). ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN TOLL-LIKE RECEPTORS WITH ACINETOBACTER BAUMANII INFECTIONIN A CHINESE POPULATION. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(1), 20-26. SID. https://sid.ir/paper/273972/en

    Vancouver: Copy

    AMOURACHE LEILA, LIN MAOHU, FAN WENSHENG, LIU YUNXI, SUO JIJIANG, XING YUBIN, JIA NING. ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN TOLL-LIKE RECEPTORS WITH ACINETOBACTER BAUMANII INFECTIONIN A CHINESE POPULATION. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(1):20-26. Available from: https://sid.ir/paper/273972/en

    IEEE: Copy

    LEILA AMOURACHE, MAOHU LIN, WENSHENG FAN, YUNXI LIU, JIJIANG SUO, YUBIN XING, and NING JIA, “ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN TOLL-LIKE RECEPTORS WITH ACINETOBACTER BAUMANII INFECTIONIN A CHINESE POPULATION,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 1, pp. 20–26, 2016, [Online]. Available: https://sid.ir/paper/273972/en

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