WHOLE EXOME SEQUENCING OF CHRONIC MYELOID LEUKEMIA PATIENTS

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SABRI SHAGHAYEGH; KEYHANI MANOUCHEHR; AKBARI MOHAMMAD TAGHI

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Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2016 | Volume:45 | Issue:3 Page(s): 346-352

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Information Journal Paper

Title

WHOLE EXOME SEQUENCING OF CHRONIC MYELOID LEUKEMIA PATIENTS

Author(s)

SABRI SHAGHAYEGH | KEYHANI MANOUCHEHR | AKBARI MOHAMMAD TAGHI | Issue Writer Certificate

Keywords

CML

WHOLE EXOME SEQUENCING

IRAN

Abstract

Background: Previous studies have shown that leukemogenic chromosomal translocations, including fusions be-tween Break point Cluster Region (BCR) and Abelson (ABL) are present in the peripheral blood of healthy individu-als. The aim of this study was to gain insights into the genetic alterations other than BCR-Abl translocation in molecu-lar level, which cause chronic myeloid leukemia (CML).Methods: We performed whole-exome sequencing on four cases representative of BCR-ABL positive CML in chron-ic phase of the disease.Results: We did not identify any pathogenic mutation in all known genes involved in CML or other cancers in our subjects. Nevertheless, we identified polymorphisms in related genes.Conclusion: It is the first report of exome sequencing in Philadelphia chromosome positive CML patients. We did not identify any pathogenic mutation in known cancer genes in our patients who can be due to CML pathogenesis or technical limitations.

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APA: Copy

SABRI, SHAGHAYEGH, KEYHANI, MANOUCHEHR, & AKBARI, MOHAMMAD TAGHI. (2016). WHOLE EXOME SEQUENCING OF CHRONIC MYELOID LEUKEMIA PATIENTS. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(3), 346-352. SID. https://sid.ir/paper/274012/en

Vancouver: Copy

SABRI SHAGHAYEGH, KEYHANI MANOUCHEHR, AKBARI MOHAMMAD TAGHI. WHOLE EXOME SEQUENCING OF CHRONIC MYELOID LEUKEMIA PATIENTS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(3):346-352. Available from: https://sid.ir/paper/274012/en

IEEE: Copy

SHAGHAYEGH SABRI, MANOUCHEHR KEYHANI, and MOHAMMAD TAGHI AKBARI, “WHOLE EXOME SEQUENCING OF CHRONIC MYELOID LEUKEMIA PATIENTS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 3, pp. 346–352, 2016, [Online]. Available: https://sid.ir/paper/274012/en

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