EFFICACY AND SAFETY OF G2013 AS A NOVEL IMMUNOSUPPRESSIVE AGENT ON DIFFERENTIATION, MATURATION AND FUNCTION OF HUMAN DENDRITIC CELLS

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ARJOMAND FARD NAZANIN; TABRIZIAN Nakisa; MIRZAEI REZA; HADJATI JAMSHID; TOFIGHI ZAVAREH FARZANEH; SALEHI NODEH Ali Reza; MIR SHAFIEY Abbas

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Journal: Iranian Journal of Public Health Year:2017 | Volume:46 | Issue:2 Page(s): 0-0

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Title

EFFICACY AND SAFETY OF G2013 AS A NOVEL IMMUNOSUPPRESSIVE AGENT ON DIFFERENTIATION, MATURATION AND FUNCTION OF HUMAN DENDRITIC CELLS

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Keywords

NSAIDS

ANTI-INFLAMMATORY AGENTS

DENDRITIC CELL

IMMUNOSUPPRESSIVE

Abstract

Background: The expanse of DENDRITIC CELLs (DC) differentiation plays an important role in determining immune re-sponse. DC-based IMMUNOSUPPRESSIVE drugs have notable side effects in increasing the risk of infectious diseases and cancers. G2013, as a novel anti-inflammatory and IMMUNOSUPPRESSIVE agent, has been tested in experimental model of multiple sclerosis. The aim of this study was to conduct the safety property of G2013 on DENDRITIC CELLs biology.Methods: The effect of G2013 on differentiation, maturation, and function of DENDRITIC CELLs was examined at Tehran University in 2014. To investigate how G2013 affects human DENDRITIC CELLs (DC) in a defined inflammatory environ-ment, human peripheral blood mononuclear cells (PBMC) were isolated from healthy blood. Monocytes were then purified using anti-CD14 microbeads. Monocytes were treated with G2013 in two different doses (6 and 12 mg/well) along with adding granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 for inducing mono-cytes to immature DC and adding lipopolysaccharide for running DC maturation. Differentiation, maturation, and function of DENDRITIC CELLs were examined with flow cytometry and ELISA.Results: G2013 therapy had no significant effect on CD83, CD86 and DR expression, as well as IL-10 and IL-12 cytokine levels and it, has no remarkable side on differentiation, maturation and function of DENDRITIC CELLs in imma-ture DC and mature DC process in vitro.Conclusion: G2013 is a safe agent with no adverse effect on differentiation, maturation, and function of DENDRITIC CELLs. It may be recommended as a novel IMMUNOSUPPRESSIVE agent with no or little side effect in increasing the risk of infectious diseases and cancers.

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APA: Copy

ARJOMAND FARD, NAZANIN, TABRIZIAN, Nakisa, MIRZAEI, REZA, HADJATI, JAMSHID, TOFIGHI ZAVAREH, FARZANEH, SALEHI NODEH, Ali Reza, & MIR SHAFIEY, Abbas. (2017). EFFICACY AND SAFETY OF G2013 AS A NOVEL IMMUNOSUPPRESSIVE AGENT ON DIFFERENTIATION, MATURATION AND FUNCTION OF HUMAN DENDRITIC CELLS. IRANIAN JOURNAL OF PUBLIC HEALTH, 46(2), 0-0. SID. https://sid.ir/paper/274082/en

Vancouver: Copy

ARJOMAND FARD NAZANIN, TABRIZIAN Nakisa, MIRZAEI REZA, HADJATI JAMSHID, TOFIGHI ZAVAREH FARZANEH, SALEHI NODEH Ali Reza, MIR SHAFIEY Abbas. EFFICACY AND SAFETY OF G2013 AS A NOVEL IMMUNOSUPPRESSIVE AGENT ON DIFFERENTIATION, MATURATION AND FUNCTION OF HUMAN DENDRITIC CELLS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2017;46(2):0-0. Available from: https://sid.ir/paper/274082/en

IEEE: Copy

NAZANIN ARJOMAND FARD, Nakisa TABRIZIAN, REZA MIRZAEI, JAMSHID HADJATI, FARZANEH TOFIGHI ZAVAREH, Ali Reza SALEHI NODEH, and Abbas MIR SHAFIEY, “EFFICACY AND SAFETY OF G2013 AS A NOVEL IMMUNOSUPPRESSIVE AGENT ON DIFFERENTIATION, MATURATION AND FUNCTION OF HUMAN DENDRITIC CELLS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 46, no. 2, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/274082/en

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