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Information Journal Paper

Title

THE ROLE OF NT-PROBNP IN THE DIAGNOSIS OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH SYSTEMIC SCLEROSIS

Pages

  906-916

Abstract

 Background: In patients with SYSTEMIC SCLEROSIS, NT-PROBNP is a useful diagnostic marker for pulmonary hypertensionand ventricular dysfunction, with important prognostic significance. The aim of this study was to assess the relationshipbetween the NT-PROBNP levels and the presence and severity of VENTRICULAR ARRHYTHMIAS in patients with scleroderma.Methods: Forty consecutive patients with a diagnostic of SYSTEMIC SCLEROSIS according to the EULAR criteria admittedat the Rheumatology Clinic of Cluj-Napoca, Romania, from Jan 2014 to Apr 2014 were enrolled. Patients underwent a12-lead ECG and a 24-hour Holter ECG monitoring for VENTRICULAR ARRHYTHMIAS evaluation. Blood sample testing (includingNT-proBNP level measurements), echocardiography, spirometry, chest X-ray and, when considered appropriate, high-resolution chest CT were performed.Results: Sixty percent of patients (n=24) had abnormal NT-PROBNP serum levels (>125 pg/ml) and 10 patients had>100 PVC /24 h. There was a statistically significant correlation between the NT-PROBNP levels and the total numberof premature ventricular contractions (PVC) (r=0.445, P=0.006), total number of isolated PVC (r=0, 493, P=0.002), total number of ventricular couplets (r=0.379, P=0.021) and the number of PVC morphologies (r=0.501, P=0.002).The presence of an NT-PROBNP serum level>287 pg/ml had a sensitivity of 55% and a specificity of 93% in predictingthe presence of complex VENTRICULAR ARRHYTHMIAS on 24-hour Holter ECG monitoring.Conclusion: NT-PROBNP levels could become a useful ventricular arrhythmia marker for assessing the arrhythmicrisk in patients with SYSTEMIC SCLEROSIS.

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    APA: Copy

    MURESAN, LUCIAN. (2017). THE ROLE OF NT-PROBNP IN THE DIAGNOSIS OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH SYSTEMIC SCLEROSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 46(7), 906-916. SID. https://sid.ir/paper/274182/en

    Vancouver: Copy

    MURESAN LUCIAN. THE ROLE OF NT-PROBNP IN THE DIAGNOSIS OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH SYSTEMIC SCLEROSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2017;46(7):906-916. Available from: https://sid.ir/paper/274182/en

    IEEE: Copy

    LUCIAN MURESAN, “THE ROLE OF NT-PROBNP IN THE DIAGNOSIS OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH SYSTEMIC SCLEROSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 46, no. 7, pp. 906–916, 2017, [Online]. Available: https://sid.ir/paper/274182/en

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