ASSOCIATION OF THE −243A>G, +61450C>A POLYMORPHISMS OF THE GLUTAMATE DECARBOXYLASE 2 (GAD2) GENE WITH OBESITY AND INSULIN LEVEL IN NORTH INDIAN POPULATION

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PRAKASH JAI; MITTAL BALRAJ; AWASTHI SHALLY; SRIVASTAVA NEENA

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Journal: Iranian Journal of Public Health Year:2016 | Volume:45 | Issue:4 Page(s): 460-468

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Information Journal Paper

Title

ASSOCIATION OF THE −243A>G, +61450C>A POLYMORPHISMS OF THE GLUTAMATE DECARBOXYLASE 2 (GAD2) GENE WITH OBESITY AND INSULIN LEVEL IN NORTH INDIAN POPULATION

Author(s)

PRAKASH JAI | MITTAL BALRAJ | AWASTHI SHALLY | SRIVASTAVA NEENA | Issue Writer Certificate

Keywords

OBESITY

INSULIN

GAD-2

FOOD INTAKE

POLYMORPHISM

Abstract

Background: OBESITY associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with OBESITY and it regulate FOOD INTAKE and INSULIN level. We investigated the association of GAD-2gene −243A>G (rs2236418) and+61450C>A (rs992990) POLYMORPHISMs with OBESITY and related phenotypes.Methods: INSULIN, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method.Results: The −243A>G POLYMORPHISM of the GAD-2 gene was significantly associated with higher risk of OBESITY (P<0.05).Conclusion: GAD-2 gene POLYMORPHISMs influence OBESITY and related phenotype in complex manner, probably by regulating the FOOD INTAKE, INSULIN and body weight.

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APA: Copy

PRAKASH, JAI, AWASTHI, SHALLY, & SRIVASTAVA, NEENA. (2016). ASSOCIATION OF THE ?243A>G, +61450C>A POLYMORPHISMS OF THE GLUTAMATE DECARBOXYLASE 2 (GAD2) GENE WITH OBESITY AND INSULIN LEVEL IN NORTH INDIAN POPULATION. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(4), 460-468. SID. https://sid.ir/paper/274231/en

Vancouver: Copy

PRAKASH JAI, AWASTHI SHALLY, SRIVASTAVA NEENA. ASSOCIATION OF THE ?243A>G, +61450C>A POLYMORPHISMS OF THE GLUTAMATE DECARBOXYLASE 2 (GAD2) GENE WITH OBESITY AND INSULIN LEVEL IN NORTH INDIAN POPULATION. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(4):460-468. Available from: https://sid.ir/paper/274231/en

IEEE: Copy

JAI PRAKASH, SHALLY AWASTHI, and NEENA SRIVASTAVA, “ASSOCIATION OF THE ?243A>G, +61450C>A POLYMORPHISMS OF THE GLUTAMATE DECARBOXYLASE 2 (GAD2) GENE WITH OBESITY AND INSULIN LEVEL IN NORTH INDIAN POPULATION,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 4, pp. 460–468, 2016, [Online]. Available: https://sid.ir/paper/274231/en

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