LOWER SERUM LEVELS OF URIC ACID IN UTERINE FI¬BROIDS AND FIBRO-CYSTIC BREAST DISEASE PATIENTS IN DONGYING CITY, CHINA

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CHEN QICAI; XIAO Juan; ZHANG Pengpeng; CHEN Lili; CHEN Xiaoxiao; WANG Shumei

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Journal: Iranian Journal of Public Health Year:2016 | Volume:45 | Issue:5 Page(s): 595-605

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Title

LOWER SERUM LEVELS OF URIC ACID IN UTERINE FI¬BROIDS AND FIBRO-CYSTIC BREAST DISEASE PATIENTS IN DONGYING CITY, CHINA

Author(s)

Keywords

URIC ACID

ESTROGENIC EFFECT

LEIOMYOMA AND FIBROCYST

BREAST DISEASE

Abstract

Background: Increasing serum levels of URIC ACID (SUA) after menopause in women brought up a hypothesis that ESTROGENIC EFFECT may protectively regulate SUA. ESTROGENIC EFFECT is a major etiology of uterine fibroids and fibrocystic BREAST DISEASE. The study aimed to explore SUA among patients suffering from these diseases to enhance the hypothesis.Methods: Overall, 1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic BREAST DISEASE (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic BREAST DISEASE (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode.Results: From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (P=0.011), 5.88umol/L (P=0.014) and 9.39 umol/L (P=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (P=0.003).Conclusion: Participants of uterine fibroids and fibrocystic BREAST DISEASE had a lower SUA except the stage of menopause, which indirectly supported that ESTROGENIC EFFECT, may protectively decrease SUA.

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APA: Copy

CHEN, QICAI, XIAO, Juan, ZHANG, Pengpeng, CHEN, Lili, CHEN, Xiaoxiao, & WANG, Shumei. (2016). LOWER SERUM LEVELS OF URIC ACID IN UTERINE FI¬BROIDS AND FIBRO-CYSTIC BREAST DISEASE PATIENTS IN DONGYING CITY, CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(5), 595-605. SID. https://sid.ir/paper/274267/en

Vancouver: Copy

CHEN QICAI, XIAO Juan, ZHANG Pengpeng, CHEN Lili, CHEN Xiaoxiao, WANG Shumei. LOWER SERUM LEVELS OF URIC ACID IN UTERINE FI¬BROIDS AND FIBRO-CYSTIC BREAST DISEASE PATIENTS IN DONGYING CITY, CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(5):595-605. Available from: https://sid.ir/paper/274267/en

IEEE: Copy

QICAI CHEN, Juan XIAO, Pengpeng ZHANG, Lili CHEN, Xiaoxiao CHEN, and Shumei WANG, “LOWER SERUM LEVELS OF URIC ACID IN UTERINE FI¬BROIDS AND FIBRO-CYSTIC BREAST DISEASE PATIENTS IN DONGYING CITY, CHINA,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 5, pp. 595–605, 2016, [Online]. Available: https://sid.ir/paper/274267/en

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