ASSOCIATION BETWEEN FEN1 POLYMORPHISMS -69G>A AND 4150G>T WITH SUSCEPTIBILITY IN HUMAN DISEASE: A META-ANALYSIS

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YING NANJIAO; WANG SHUO; XU HONG; WANG YANYI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2015 | Volume:44 | Issue:12 Page(s): 1574-1579

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Title

ASSOCIATION BETWEEN FEN1 POLYMORPHISMS -69G>A AND 4150G>T WITH SUSCEPTIBILITY IN HUMAN DISEASE: A META-ANALYSIS

Author(s)

YING NANJIAO | WANG SHUO | XU HONG | WANG YANYI | Issue Writer Certificate

Keywords

FLAP ENDONUCLEASE 1

GENETIC VARIANTS

SNPS

SUSCEPTIBILITY

DISEASE

Abstract

Background: As a DNA repair protein, FLAP ENDONUCLEASE 1 is a key enzyme in maintaining genomic instability and preventing carcinogenesis. Two single nucleotide polymorphisms (SNPs), -69G>A and 4150G>T are associated with DNA damage. This meta-analysis is to evaluate the genetic effects of FEN1 gene SNPS (-69G/A and 4150G/T) and the SUSCEPTIBILITY to DISEASEs, including glioma risk, breast cancer, lung cancer, keratoconus (KC) and fuchs’ endothelial corneal dystrophy (FECD).Methods: A literature search of PubMed and Embase was conducted to identify all eligible published studies. Five case-control studies were included with a total of 5612 cases and 6703 controls in this meta-analysis. Crude odds ratios (ORs) with their corresponding confidence intervals (95%CI) were used to assess the strength of the association.Results: The FEN1 -69G/A and 4150G/T polymorphisms were significantly associated with the DISEASE risk. Our meta-analysis showed the FEN1 -69GG genotype was correlated to increase risk for the contained DISEASEs compared with the -69AG genotype (OR=0.77, 95%CI=0.71~0.83). Moreover, the FEN1 4150GG genotype could increase DISEASEs risk compared with the 4150TG genotype (OR=0.81, 95%CI=0.75~0.87).Conclusion: The variant genotypes of the FEN1 -69G/A and FEN1 4150G/T polymorphisms may be associated with DISEASEs SUSCEPTIBILITY. However, more studies are needed to detect the DISEASE risk in different ethnic popula-tions.

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