EFFECT OF SOY ISOFLAVONE ON HOT FLUSHES, ENDOMETRIAL THICKNESS, AND BREAST CLINICAL AS WELL AS SONOGRAPHIC FEATURES

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VAHID DASTJERDI MARZIYEH; ESLAMI BITA; SHARIFI MARYAM ALSADAT; MOINI ASHRAF; BAYANI LEILA; MOHAMMAD KHANI HODA; ALIPOUR SADAF

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Journal: Iranian Journal of Public Health Year:2018 | Volume:47 | Issue:3 Page(s): 382-389

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Title

EFFECT OF SOY ISOFLAVONE ON HOT FLUSHES, ENDOMETRIAL THICKNESS, AND BREAST CLINICAL AS WELL AS SONOGRAPHIC FEATURES

Author(s)

Keywords

ISOFLAVONE

HOT FLUSHES

BREAST TISSUE

ENDOMETRIAL THICKNESS

Abstract

Background: Phytoestrogens treatment to relieve HOT FLUSHES in menopausal women was considered recently. However, the actual effectiveness and safety are not clear. Methods: Randomized clinical trial (IRCT#20100706004329N5) was performed in 204 patients who com-plained of HOT FLUSHES in Arash Women's Hospital, Tehran, Iran from 2013-2015. The first group received 50 mg ISOFLAVONE (group A) once daily and the second group received placebo (group B) in the same regimen. Pa-tients were evaluated for breast examination (BE) and breast sonography (BS) as well as vaginal sonography at initial presentation and at 6th and 12th week follow-ups. Patients were educated to record frequency and se-verity of HOT FLUSHES. Results: Group A experienced less HOT FLUSHES attack (6 vs 9 patients with 5< attacks in 6 wk (P= 0. 05), 7 Vs 13 patients with 5< in 12 wk (P=0. 01)) which was also less severe (8 vs 12 patients with severe symptoms in 6 wk (0. 04) and 3 Vs 10 patients with severe symptoms in 12 wk (0. 001). ISOFLAVONE had no effect on neither breast density nor nodularity (in 6 wk, P=0. 50 and 0. 80, respectively and in 12 wk, P=0. 32 and 0. 43) and nei-ther breast tenderness nor nipple discharge (in 6 wk, P=0. 40 and 0. 34 respectively and in 12 wk, P= 0. 31 and 0. 26). There were no significant differences in ENDOMETRIAL THICKNESS in 6 and 12wk. Conclusion: Effects of ISOFLAVONE on frequency and severity of HOT FLUSHES in perimenopausal women is ob-served. Some clinical and ultrasonographic benign non-significant changes of the breast and endometrium are noted after ISOFLAVONE intake.

Cites

Phytoestrogens and Breast Diseases: A Matter of Concern for the Gynecologist

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APA: Copy

VAHID DASTJERDI, MARZIYEH, ESLAMI, BITA, SHARIFI, MARYAM ALSADAT, MOINI, ASHRAF, BAYANI, LEILA, MOHAMMAD KHANI, HODA, & ALIPOUR, SADAF. (2018). EFFECT OF SOY ISOFLAVONE ON HOT FLUSHES, ENDOMETRIAL THICKNESS, AND BREAST CLINICAL AS WELL AS SONOGRAPHIC FEATURES. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(3), 382-389. SID. https://sid.ir/paper/274470/en

Vancouver: Copy

VAHID DASTJERDI MARZIYEH, ESLAMI BITA, SHARIFI MARYAM ALSADAT, MOINI ASHRAF, BAYANI LEILA, MOHAMMAD KHANI HODA, ALIPOUR SADAF. EFFECT OF SOY ISOFLAVONE ON HOT FLUSHES, ENDOMETRIAL THICKNESS, AND BREAST CLINICAL AS WELL AS SONOGRAPHIC FEATURES. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(3):382-389. Available from: https://sid.ir/paper/274470/en

IEEE: Copy

MARZIYEH VAHID DASTJERDI, BITA ESLAMI, MARYAM ALSADAT SHARIFI, ASHRAF MOINI, LEILA BAYANI, HODA MOHAMMAD KHANI, and SADAF ALIPOUR, “EFFECT OF SOY ISOFLAVONE ON HOT FLUSHES, ENDOMETRIAL THICKNESS, AND BREAST CLINICAL AS WELL AS SONOGRAPHIC FEATURES,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 3, pp. 382–389, 2018, [Online]. Available: https://sid.ir/paper/274470/en

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