THE EFFECT OF FETAL HYPOTHYROIDISM ON THE SERUM AND TISSUE LEVELS OF NITRIC OXIDE METABOLITES IN ADULT MALE HYPOTHYROID PROGENY

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MEHRAZIN F.; SHIRAVI A.; ZAHEDIASL S.; GHASEMI A.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2012 | Volume:14 | Issue:6 (SN 66) Page(s): 524-530

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Title

THE EFFECT OF FETAL HYPOTHYROIDISM ON THE SERUM AND TISSUE LEVELS OF NITRIC OXIDE METABOLITES IN ADULT MALE HYPOTHYROID PROGENY

Author(s)

MEHRAZIN F. | SHIRAVI A. | ZAHEDIASL S. | GHASEMI A. | Issue Writer Certificate

Keywords

FETAL HYPOTHYROIDISMQ2

NITRIC OXIDEQ2

RATQ2

Abstract

Introduction: Decreased NITRIC OXIDE (NO) synthesis has been reported in hypothyroidism. Nitrate consumption is associated with increased serum NO metabolites, nitrate and nitrite (NOx). The aim of this study was to evaluate NOx levels in serum and heart, aorta, and lung tissues of the offspring of hypothyroid RATs.Materials and Methods: Hypothyroidism was induced in female RATs using 6-n-propylthiouracil in drinking water from the beginning to the end of gestation. Fetal male offspring with and without FETAL HYPOTHYROIDISM were followed until adulthood and then divided into four groups including the control and hypothyroidism groups with injection of sodium nitrate (10 mg/kg, ip), and the control and hypothyroidism groups without injection. NOx concentrations in serum and tissue samples were measured using the Griess assay.Results: Serum NOx concentrations in both groups reached a maximum one hour after nitrate injection. NOx level decreased in both groups after the first hour with a steeper slope in fetal hypothyroid RATs. Heart and aorta NOx concentrations were significantly lower than controls in fetal hypothyroid group. Following nitrate injection, the NOx concentration in the controls group increased in the heart and lung tissues, but significant increases were observed in all three tissues in the fetal hypothyroid group.Conclusion: NOx metabolism differs in fetal hypothyroid and control RATs and the role of thyroid hormones in NOx metabolism persists until adulthood.

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APA: Copy

MEHRAZIN, F., SHIRAVI, A., ZAHEDIASL, S., & GHASEMI, A.. (2012). THE EFFECT OF FETAL HYPOTHYROIDISM ON THE SERUM AND TISSUE LEVELS OF NITRIC OXIDE METABOLITES IN ADULT MALE HYPOTHYROID PROGENY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 14(6 (SN 66)), 524-530. SID. https://sid.ir/paper/27452/en

Vancouver: Copy

MEHRAZIN F., SHIRAVI A., ZAHEDIASL S., GHASEMI A.. THE EFFECT OF FETAL HYPOTHYROIDISM ON THE SERUM AND TISSUE LEVELS OF NITRIC OXIDE METABOLITES IN ADULT MALE HYPOTHYROID PROGENY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;14(6 (SN 66)):524-530. Available from: https://sid.ir/paper/27452/en

IEEE: Copy

F. MEHRAZIN, A. SHIRAVI, S. ZAHEDIASL, and A. GHASEMI, “THE EFFECT OF FETAL HYPOTHYROIDISM ON THE SERUM AND TISSUE LEVELS OF NITRIC OXIDE METABOLITES IN ADULT MALE HYPOTHYROID PROGENY,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 14, no. 6 (SN 66), pp. 524–530, 2012, [Online]. Available: https://sid.ir/paper/27452/en

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