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Information Journal Paper

Title

RELATIONSHIP BETWEEN SERUM SOLUBLE KLOTHO PROTEIN ANDCORONARY ARTERY CALCIFICATION AND PROGNOSIS IN PATIENTS ON MAINTENANCE HEMODIALYSIS

Pages

  510-518

Abstract

 Background: We aimed to investigate the relationship between serum SOLUBLE KLOTHO PROTEIN (sKlotho) level and CORONARY ARTERY CALCIFICATION (CAC) as well as prognosis in patients with maintenance hemodialysis (MHD). Methods: Overall, 128 adult patients with end-stage renal failure treated with MHD were collected in the Sec-ond Affiliated Hospital & Yuying Children’ s Hospital of Wenzhou Medical University, Zhejiang Province, China in 2013. Serum sKlotho was detected by ELISA and CORONARY ARTERY CALCIFICATION was measured by mul-ti-slice spiral computed tomography (MSCT). With 36 months' follow-up, death notes such as cause of death and death time were recorded. Results: Patients were divided into low sKlotho group and high sKlotho group. Age, blood phosphorus level, hypertension incidence and incidence of diabetes mellitus of the patients in low sKlotho group was significant-ly higher than that of high sKlotho group (P<0. 05). The CORONARY ARTERY CALCIFICATION score (CACs) of patients in high sKlotho group was significantly lower than that of low sKlotho group (P<0. 001). Logistic regression showed that the decrease of sKlotho level (P<0. 001) was an independent risk factor for CAC progression. The MORTALITY of the patients in low sKlotho group was higher than that of high sKlotho group. Kaplan-Meier sur-vival curve had shown that survival time of the patients in low sKlotho group was significantly lower than that of high sKlotho group (P<0. 05). Conclusion: SKlotho can increase the degree of CAC. Although MHD patients with low sKlotho level had shorter survival time, sKlotho is not an independent risk factor in prediction of prognosis of MHD patients.

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    APA: Copy

    ZHENG, SHUBEI, ZHENG, YU, JIN, LINGWEI, ZHOU, ZHIHONG, & LI, ZHANYUAN. (2018). RELATIONSHIP BETWEEN SERUM SOLUBLE KLOTHO PROTEIN ANDCORONARY ARTERY CALCIFICATION AND PROGNOSIS IN PATIENTS ON MAINTENANCE HEMODIALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(4), 510-518. SID. https://sid.ir/paper/274531/en

    Vancouver: Copy

    ZHENG SHUBEI, ZHENG YU, JIN LINGWEI, ZHOU ZHIHONG, LI ZHANYUAN. RELATIONSHIP BETWEEN SERUM SOLUBLE KLOTHO PROTEIN ANDCORONARY ARTERY CALCIFICATION AND PROGNOSIS IN PATIENTS ON MAINTENANCE HEMODIALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(4):510-518. Available from: https://sid.ir/paper/274531/en

    IEEE: Copy

    SHUBEI ZHENG, YU ZHENG, LINGWEI JIN, ZHIHONG ZHOU, and ZHANYUAN LI, “RELATIONSHIP BETWEEN SERUM SOLUBLE KLOTHO PROTEIN ANDCORONARY ARTERY CALCIFICATION AND PROGNOSIS IN PATIENTS ON MAINTENANCE HEMODIALYSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 4, pp. 510–518, 2018, [Online]. Available: https://sid.ir/paper/274531/en

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