ROLE OF MOLECULAR BIOLOGY IN CANCER TREATMENT: A REVIEW ARTICLE

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IMRAN AMAN; QAMAR HAFIZA YASARA; ALI QURBAN; NAEEM HAFSA; RIAZ MARIAM; Amin Saima; KANWAL NAILA; ALI FAWAD; SABAR MUHAMMAD FAROOQ; NASIR IDREES AHMAD

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Journal: Iranian Journal of Public Health Year:2017 | Volume:46 | Issue:11 Page(s): 1475-1485

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Title

ROLE OF MOLECULAR BIOLOGY IN CANCER TREATMENT: A REVIEW ARTICLE

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Keywords

CANCER

ONCOGENES

PROTO-ONCOGENES

MUTAGENESIS

VIRAL INFECTION

TUMOR

CRISPR

Abstract

Background: CANCER is a genetic disease and mainly arises due to a number of reasons include activation of onco-genes, malfunction of TUMOR suppressor genes or MUTAGENESIS due to external factors. Methods: This article was written from the data collected from PubMed, Nature, Science Direct, Springer and Elsevi-er groups of journals. Results: ONCOGENES are deregulated form of normal PROTO-ONCOGENES required for cell division, differentiation and regulation. The conversion of proto-oncogene to oncogene is caused due to translocation, rearrangement of chromo-somes or mutation in gene due to addition, deletion, duplication or VIRAL INFECTION. These ONCOGENES are targeted by drugs or RNAi system to prevent proliferation of CANCERous cells. There have been developed different techniques of molecular biology used to diagnose and treat CANCER, including retroviral therapy, silencing of ONCOGENES and muta-tions in TUMOR suppressor genes. Conclusion: Among all the techniques used, RNAi, zinc finger nucleases and CRISPR hold a brighter future towards creating a CANCER Free World.

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APA: Copy

IMRAN, AMAN, QAMAR, HAFIZA YASARA, ALI, QURBAN, NAEEM, HAFSA, RIAZ, MARIAM, Amin, Saima, KANWAL, NAILA, ALI, FAWAD, SABAR, MUHAMMAD FAROOQ, & NASIR, IDREES AHMAD. (2017). ROLE OF MOLECULAR BIOLOGY IN CANCER TREATMENT: A REVIEW ARTICLE. IRANIAN JOURNAL OF PUBLIC HEALTH, 46(11), 1475-1485. SID. https://sid.ir/paper/274665/en

Vancouver: Copy

IMRAN AMAN, QAMAR HAFIZA YASARA, ALI QURBAN, NAEEM HAFSA, RIAZ MARIAM, Amin Saima, KANWAL NAILA, ALI FAWAD, SABAR MUHAMMAD FAROOQ, NASIR IDREES AHMAD. ROLE OF MOLECULAR BIOLOGY IN CANCER TREATMENT: A REVIEW ARTICLE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2017;46(11):1475-1485. Available from: https://sid.ir/paper/274665/en

IEEE: Copy

AMAN IMRAN, HAFIZA YASARA QAMAR, QURBAN ALI, HAFSA NAEEM, MARIAM RIAZ, Saima Amin, NAILA KANWAL, FAWAD ALI, MUHAMMAD FAROOQ SABAR, and IDREES AHMAD NASIR, “ROLE OF MOLECULAR BIOLOGY IN CANCER TREATMENT: A REVIEW ARTICLE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 46, no. 11, pp. 1475–1485, 2017, [Online]. Available: https://sid.ir/paper/274665/en

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