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Information Journal Paper

Title

COMPARISON OF TICAGRELOR AND CLOPIDOGREL FOR PATIENTS UNDERGOING EMERGENCY PERCUTANEOUS CORONARY INTERVENTION

Pages

  952-957

Abstract

 Background: We compared treatments with the antiplatelets TICAGRELOR and clopidogrel used in patients with ACUTE MYOCARDIAL INFARCTION (AMI) during the perioperative period for emergency percutaneous coronary inter-vention (PCI). Methods: A total of 120 patients were selected and randomly divided into control and observation groups (60 patients in each) from 2014-2016 at The Affiliated Hospital of Qingdao University. The patients in the con-trol group received 300 mg clopidogrel and 300 mg aspirin for oral administration, while those in the observa-tion group were given 180 mg TICAGRELOR and 300 mg aspirin orally prior to the PCI. During the operation, heparinization and a tirofiban micro-pump were used continuously. Results: Coronary artery and peripheral venous blood were extracted from each patient to obtain various pa-rameters of THROMBELASTOGRAM (TEG), and the maximum platelet aggregation rates in order to compare an-tiplatelet effects. MAJOR ADVERSE CARDIAC EVENTS (MACE) were recorded during the following 6-month follow-up. Analysis of the data showed no differences in terms of the time span between medication intake and stent implantation, or the dosage of heparin and tirofiban used between the two groups. Before stent implantation, and 24 and 48 h after the procedure the average R and K values of TEG in coronary artery blood and periph-eral venous blood samples in the observation group were longer than those in the control group, while the α angle, MA, CI, MARAA and MARADP values were lower (P<0. 05). Conclusion: TICAGRELOR can improve antiplatelet treatment for patients with AMI during the perioperative period of emergency PCI.

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    APA: Copy

    YANG, BIN, ZHENG, CHUNYAN, YU, HAICHU, ZHANGN, RUI, LI, SHAN, TAN, LIJUAN, LENG, MIN, & CAI, SHANGLANG. (2018). COMPARISON OF TICAGRELOR AND CLOPIDOGREL FOR PATIENTS UNDERGOING EMERGENCY PERCUTANEOUS CORONARY INTERVENTION. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(7), 952-957. SID. https://sid.ir/paper/274820/en

    Vancouver: Copy

    YANG BIN, ZHENG CHUNYAN, YU HAICHU, ZHANGN RUI, LI SHAN, TAN LIJUAN, LENG MIN, CAI SHANGLANG. COMPARISON OF TICAGRELOR AND CLOPIDOGREL FOR PATIENTS UNDERGOING EMERGENCY PERCUTANEOUS CORONARY INTERVENTION. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(7):952-957. Available from: https://sid.ir/paper/274820/en

    IEEE: Copy

    BIN YANG, CHUNYAN ZHENG, HAICHU YU, RUI ZHANGN, SHAN LI, LIJUAN TAN, MIN LENG, and SHANGLANG CAI, “COMPARISON OF TICAGRELOR AND CLOPIDOGREL FOR PATIENTS UNDERGOING EMERGENCY PERCUTANEOUS CORONARY INTERVENTION,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 7, pp. 952–957, 2018, [Online]. Available: https://sid.ir/paper/274820/en

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