REPRODUCTIVE HORMONAL CHANGES FOLLOWING TWO TYPES OF HYPOCALORIC DIETS IN OVERWEIGHT AND OBESE POLYCYSTIC OVARY SYNDROME WOMEN

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HAMAYELI MEHRABANI H.; TAHBAZ F.; SALEHPOUE S.; HEDAYATI M.; AMIRI Z.; GHASSEMI A.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2010 | Volume:12 | Issue:2 (SN 50) Page(s): 160-168

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Title

REPRODUCTIVE HORMONAL CHANGES FOLLOWING TWO TYPES OF HYPOCALORIC DIETS IN OVERWEIGHT AND OBESE POLYCYSTIC OVARY SYNDROME WOMEN

Author(s)

Keywords

PCOSQ2

WEIGHT LOSSQ2

HYPOCALORIC DIETQ3

OBESITYQ2

REPRODUCTIVE HORMONESQ3

Abstract

Introduction: The appropriate combination and composition of HYPOCALORIC DIETs for obese women with polycystic ovary syndrome (PCDS) is still unclear. The aim of this study was to investigate the effects of a high protein-low glycaemic load diet on REPRODUCTIVE HORMONES in obese women with PCDS.Materials and Methods: In this single blind clinical trial, sixty overweight and obese women with PCDS, not using metformin, were randomly assigned in-one of two groups, the modified with a 30% protein-low glycaemic load diet, and the conventional with 15% protein. REPRODUCTIVE HORMONES, glucose and insulin were measured for 49 subjects at baseline and after 12 weeks.Results: WEIGHT LOSS showed no significant difference in the two groups. Changes in means for testosterone in the modified and conventional groups (0 to 12 weeks), were 1.78±1.52 to 1.31±1.27 and 1.51±0.63 to 1.15±0.57 ng/ml, respectively (p<0.001). FSH, LH, estradiol, progesterone and prolactin did not change. Insulin and HDMA reduction was significant for modified diet (p<0.001).Conclusion: WEIGHT LOSS had a significant effect on reduction of androgens. The main effect of modified diet with high protein and low glycaemic load was observed on insulin and HDMA, a finding which should taken into consideration for women with PCDS.

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