The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese

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ZHUANPING Zeng; RIFANG Liao; QING Chen; SIDONG Chen

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Public Health Year:2018 | Volume:47 | Issue:9 Page(s): 1271-1279

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Title

The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese

Author(s)

ZHUANPING Zeng | RIFANG Liao | QING Chen | SIDONG Chen | Issue Writer Certificate

Keywords

Sirtuin 1

Type 2 diabetes mellitus

Dietary

China

Abstract

Background: To examine whether polymorphisms of SIRT1 and Dietary product intake can be implicated in Type 2 diabetes mellitus (T2DM). Methods: In this community-based, case-control study, 568 subjects (284 patients and 284 controls) were en-rolled in a community located in northern Guangzhou, China. The four polymorphisms of SIRT1 (rs4746720, rs10509291, rs2236319, rs10823116) were examined using TaqMan nuclease technology. The Dietary data were collected by an inquiring officer through face-to-face method. Results: The rs4746720 CC+TT genotype had higher risk compared with CT genotype to develop T2DM [odds ratio (OR) =1. 42, 95% confidence interval (CI) = 1. 02-1. 97]. The subjects with rs4746720 CC+TT geno-type and eat sugar food over 30g per day increased the risk of T2DM to 2. 22(1. 21-4. 06) times. The subjects with rs4746720 CC+TT genotype and smoking increased the risk of T2DM to 1. 65 (1. 10-2. 47) times. The unhealthy eating habits such as red meat, salty food, use animal fat yielded higher risks of T2DM, the OR of risk of T2DM was 2. 89 (1. 38-6. 01), 2. 73 (1. 61-4. 64) and 27. 91(9. 24-84. 32) respectively. However, the milk, soy, white meat, vegetables and low-salt diet decreased the risk of T2DM, the OR of risk of T2DM was 0. 51 (0. 29-0. 88), 0. 43 (0. 26-0. 74), 0. 51(0. 32-0. 83), 0. 21(0. 10-0. 44), 0. 28(0. 12-0. 65), 0. 35(0. 21-0. 51) respectively. Conclusion: Variants in SIRT1 with rs4746720 CC+TT genotype increased the risk of T2DM, especially with the unhealthy eating habits.

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APA: Copy

ZHUANPING, Zeng, RIFANG, Liao, QING, Chen, & SIDONG, Chen. (2018). The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(9), 1271-1279. SID. https://sid.ir/paper/274891/en

Vancouver: Copy

ZHUANPING Zeng, RIFANG Liao, QING Chen, SIDONG Chen. The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(9):1271-1279. Available from: https://sid.ir/paper/274891/en

IEEE: Copy

Zeng ZHUANPING, Liao RIFANG, Chen QING, and Chen SIDONG, “The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 9, pp. 1271–1279, 2018, [Online]. Available: https://sid.ir/paper/274891/en

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