Serum Biomarkers AFP, CEA and CA19-9 Combined Detection for Early Diagnosis of Hepatocellular Carcinoma

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EDOO Muhammad Ibrahim Alhadi; Chutturghoon Vikram Kumar; WUSU ANSAH Gyabaah Kwabena; ZHU Hai; ZHEN Tao Yang; XIE HAIYANG; ZHENG SHUSEN

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Journal: Iranian Journal of Public Health Year:2019 | Volume:48 | Issue:2 Page(s): 314-322

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Title

Serum Biomarkers AFP, CEA and CA19-9 Combined Detection for Early Diagnosis of Hepatocellular Carcinoma

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Keywords

Hepatocellular carcinoma

Primary hepatic cancer

Serum Biomarkers

Alpha fetoprotein

Carci-noembryonic antigen

Cancer antigen 199

Abstract

Background: We aimed to evaluate the whether AFP levels alone is an adequate screening indicator, or a combination of Generally, alpha-fetoprotein (AFP), CA19-9 and CEA could provide a better diagnostic tool in detecting and screening asymptomatic patients with Primary hepatic cancer (PHC), and also evaluate the correlation of degree of differentiation with serum biomarker levels. Methods: We retrospectively reviewed the medical records of 1362 patients form 2014-2018 who visited the first Affiliated Hospital of Zhejiang University, Hangzhou, China for health check-ups or were diagnosed with cancer or cirrhosis. We then analyzed preoperative tumor markers level of AFP, CA19-9, and CEA. The standard reference values (AFP ≤ 20 ng/L CEA ≤ 5 ng/L, and CA19-9 ≤ 37 U/mL) were as positive or negative cut off values. Further, the histological sections of patients were categorized and correlated them with the three Serum Biomarkers. Results: Serum AFP, CEA, and CA19-9 levels in the PHC group were significantly higher compared to those with liver cirrhosis and healthy control groups (P < 0. 03). With AFP as a single tumor marker for PHC diag-nosis, it had a sensitivity of 63. 3% with a specificity of 80. 8%. AFP combined with CA19-9 and CEA showed specificity of 100%, a sensitivity 2. 5% with the positive and negative predictive values of 100% and 22% re-spectively. Furthermore, histological evaluation revealed the highest AFP level of 9366. 14± 23902. 61 ng/L associated with poorly differentiated HCC, while well-differentiated HCC, had the lowest mean AFP level of 45. 19± 181. 27 ng/L. Conclusion: Combined serum levels of AFP, CA19-9 and CEA does not provide a superior advantage over AFP alone as a screening and diagnostic tool for HCC detection.

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APA: Copy

EDOO, Muhammad Ibrahim Alhadi, Chutturghoon, Vikram Kumar, WUSU ANSAH, Gyabaah Kwabena, ZHU, Hai, ZHEN, Tao Yang, XIE, HAIYANG, & ZHENG, SHUSEN. (2019). Serum Biomarkers AFP, CEA and CA19-9 Combined Detection for Early Diagnosis of Hepatocellular Carcinoma. IRANIAN JOURNAL OF PUBLIC HEALTH, 48(2), 314-322. SID. https://sid.ir/paper/274985/en

Vancouver: Copy

EDOO Muhammad Ibrahim Alhadi, Chutturghoon Vikram Kumar, WUSU ANSAH Gyabaah Kwabena, ZHU Hai, ZHEN Tao Yang, XIE HAIYANG, ZHENG SHUSEN. Serum Biomarkers AFP, CEA and CA19-9 Combined Detection for Early Diagnosis of Hepatocellular Carcinoma. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2019;48(2):314-322. Available from: https://sid.ir/paper/274985/en

IEEE: Copy

Muhammad Ibrahim Alhadi EDOO, Vikram Kumar Chutturghoon, Gyabaah Kwabena WUSU ANSAH, Hai ZHU, Tao Yang ZHEN, HAIYANG XIE, and SHUSEN ZHENG, “Serum Biomarkers AFP, CEA and CA19-9 Combined Detection for Early Diagnosis of Hepatocellular Carcinoma,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 48, no. 2, pp. 314–322, 2019, [Online]. Available: https://sid.ir/paper/274985/en

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