ASSOCIATION BETWEEN SUBCLINICAL THYROID DYSFUNCTION AND CORONARY HEART DISEASE AND CARDIOVASCULAR MORTALITY: A SYSTEMATIC REVIEW

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BARGHCHI E.; AZIZI F.

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Journal Paper

Paper Information

Journal: Iranian Journal of Endocrinology & Metabolism Year:2012 | Volume:14 | Issue:4 (SN 64) Page(s): 401-409

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Title

ASSOCIATION BETWEEN SUBCLINICAL THYROID DYSFUNCTION AND CORONARY HEART DISEASE AND CARDIOVASCULAR MORTALITY: A SYSTEMATIC REVIEW

Author(s)

BARGHCHI E. | AZIZI F. | Issue Writer Certificate

Keywords

SUBCLINICAL THYROID DYSFUNCTIONQ2

CORONARY HEART DISEASEQ2

CARDIOVASCULAR MORTALITYQ2

Abstract

Introduction: The association between SUBCLINICAL THYROID DYSFUNCTION and CORONARY HEART DISEASE and CARDIOVASCULAR MORTALITY is controversial. In this cohort studiy we reviewed the association between SUBCLINICAL THYROID DYSFUNCTION and CORONARY HEART DISEASE and CARDIOVASCULAR MORTALITY.Materials and Methods: Electronic search was done in medline and PubMed from 1950 to 2010 and fourteen related studies were found. Because of the heterogenicity between studies for defenitions and adjusted variables, those with larger sample size (more than 2000) were included for final analysis.Results: Eight cohort studies met criteria for selection, but the results differed. In one study with the largest sample size the risk of CARDIOVASCULAR MORTALITY was increased in women for every one unit increase in serum TSH. In another study with a similar follow up duration of about 20 years, CORONARY HEART DISEASE events and CARDIOVASCULAR MORTALITY were increased in groups with subclinical hypothyroidism. In one study with moderate follow up of 12.5 years, the risks of CARDIOVASCULAR MORTALITY and CORONARY HEART DISEASE events were not increased in the group with SUBCLINICAL THYROID DYSFUNCTION, compared to the euthyroid group.Conclusion: We found no definite conclusion based on the studied papers. However, it seems that SUBCLINICAL THYROID DYSFUNCTION may cause an increased risk of CORONARY HEART DISEASE and CARDIOVASCULAR MORTALITY. We propose that larger cohort studies with appropropriate design for decreasing heterogenicity should be implemented, using dynamic thyroid function.

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APA: Copy

BARGHCHI, E., & AZIZI, F.. (2012). ASSOCIATION BETWEEN SUBCLINICAL THYROID DYSFUNCTION AND CORONARY HEART DISEASE AND CARDIOVASCULAR MORTALITY: A SYSTEMATIC REVIEW. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 14(4 (SN 64)), 401-409. SID. https://sid.ir/paper/27505/en

Vancouver: Copy

BARGHCHI E., AZIZI F.. ASSOCIATION BETWEEN SUBCLINICAL THYROID DYSFUNCTION AND CORONARY HEART DISEASE AND CARDIOVASCULAR MORTALITY: A SYSTEMATIC REVIEW. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;14(4 (SN 64)):401-409. Available from: https://sid.ir/paper/27505/en

IEEE: Copy

E. BARGHCHI, and F. AZIZI, “ASSOCIATION BETWEEN SUBCLINICAL THYROID DYSFUNCTION AND CORONARY HEART DISEASE AND CARDIOVASCULAR MORTALITY: A SYSTEMATIC REVIEW,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 14, no. 4 (SN 64), pp. 401–409, 2012, [Online]. Available: https://sid.ir/paper/27505/en

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