PREPARATION AND CHARACTERIZATION OF ALBUMIN MICROSPHERES ENCAPSULATED WITH PROPRANOLOL HCI

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAJADI TABASSI S.A.; RAZAVI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2003 | Volume:11 | Issue:4 Page(s): 137-141

Download Full-Text

View:

551

Download:

203

Cites:

Information Journal Paper

Title

PREPARATION AND CHARACTERIZATION OF ALBUMIN MICROSPHERES ENCAPSULATED WITH PROPRANOLOL HCI

Author(s)

SAJADI TABASSI S.A. | RAZAVI N. | Issue Writer Certificate

Keywords

ALBUMIN MICROSPHERES

PROPRANOLOL

BIOADHESION

RELEASE

SIZE DISTRIBUTION

Abstract

ALBUMIN MICROSPHERES (AMS) have found many applications in the diagnosis and treatment in recent years and more than 100 diagnostic agents and drugs have been incorporated into AMS. In the present study Bovine Serum Albumin (BSA) based microspheres bearing propranol hydrochloride were prepared by an emulsion-internal phase stabilization technique. The prepared microspheres were studied for particle SIZE DISTRIBUTION, drug loading, RELEASE characteristics, BIOADHESION and in-vitro controlled diffusion across the rat intestine. The microspheres had mean diameters between 1-25 pm of which more than 50 percent were below 5 pm. The encapsulated drug was found to be about 9% w/w of that initially added to microspheres and the superficial drug was 25% of the total amount of the encapsulated drug. Also AMS were noted to possess good BIOADHESION in such a way that about 70% of microspheres remained adherent on the surface mucosa of rat jejunum. The drug RELEASE from ALBUMIN MICROSPHERES was mainly controlled by diffusion and showed a biphasic pattern with a high initial RELEASE (burst effect), followed by a more gradual terminal RELEASE. The total amount of drug RELEASEd from microspheres after 12h was 70%. In vitro experiments on the rat intestinal segments revealed that the microspheres could effectively pass their content through intestinal membrane.

Cites

No record.

References

Cite

APA: Copy

SAJADI TABASSI, S.A., & RAZAVI, N.. (2003). PREPARATION AND CHARACTERIZATION OF ALBUMIN MICROSPHERES ENCAPSULATED WITH PROPRANOLOL HCI. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 11(4), 137-141. SID. https://sid.ir/paper/275184/en

Vancouver: Copy

SAJADI TABASSI S.A., RAZAVI N.. PREPARATION AND CHARACTERIZATION OF ALBUMIN MICROSPHERES ENCAPSULATED WITH PROPRANOLOL HCI. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2003;11(4):137-141. Available from: https://sid.ir/paper/275184/en

IEEE: Copy

S.A. SAJADI TABASSI, and N. RAZAVI, “PREPARATION AND CHARACTERIZATION OF ALBUMIN MICROSPHERES ENCAPSULATED WITH PROPRANOLOL HCI,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 11, no. 4, pp. 137–141, 2003, [Online]. Available: https://sid.ir/paper/275184/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops