SYNTHESES AND ANTICONVULSANT ACTIVITY OF N4-SUBSTITUTED TRIAZOLYLTHIAZOLES

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BINESH MARVASTI M.; SHARIFZADEH M.; JALILIAN A.R.; SOLTANINEZHAD K.; SHAFIEI A.

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2003 | Volume:11 | Issue:2 Page(s): 74-78

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Title

SYNTHESES AND ANTICONVULSANT ACTIVITY OF N4-SUBSTITUTED TRIAZOLYLTHIAZOLES

Author(s)

Keywords

4-TRIAZOLES

ANTICONVULSANT

THIAZOLES

FLUMAZENIL

PENTYLENETETRAZOLE

Abstract

Due to the good ANTICONVULSANT activity of various 1,2,4-TRIAZOLES, several new N4-substituted triazolylthiazoles were prepared by the general method for 1,2,4-triazole ring closure. ANTICONVULSANT activity of compounds was measured against PENTYLENETETRAZOLE-induced seizures in mice by intraperitoneal injections of different doses of the test compounds. Pretreatment of animals with FLUMAZENIL (10 mg/kg, i.p.) as a benzodiazepine receptors antagonist did not have any significant effect on ANTICONVULSANT activity of the test compounds. These results demonstrate that the ANTICONVULSANT activity of N4-substituted triazolylthiazole agents is not probably mediated by direct interaction with benzodiazepine receptor complex.

Cites

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES

References

SYNTHESIS AND BIOLOGICAL ACTIVITY OF THIAZOLO TRIAZOLES AS NEW ANTICONVULSANT AGENT

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APA: Copy

BINESH MARVASTI, M., SHARIFZADEH, M., JALILIAN, A.R., SOLTANINEZHAD, K., & SHAFIEI, A.. (2003). SYNTHESES AND ANTICONVULSANT ACTIVITY OF N4-SUBSTITUTED TRIAZOLYLTHIAZOLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 11(2), 74-78. SID. https://sid.ir/paper/275194/en

Vancouver: Copy

BINESH MARVASTI M., SHARIFZADEH M., JALILIAN A.R., SOLTANINEZHAD K., SHAFIEI A.. SYNTHESES AND ANTICONVULSANT ACTIVITY OF N4-SUBSTITUTED TRIAZOLYLTHIAZOLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2003;11(2):74-78. Available from: https://sid.ir/paper/275194/en

IEEE: Copy

M. BINESH MARVASTI, M. SHARIFZADEH, A.R. JALILIAN, K. SOLTANINEZHAD, and A. SHAFIEI, “SYNTHESES AND ANTICONVULSANT ACTIVITY OF N4-SUBSTITUTED TRIAZOLYLTHIAZOLES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 11, no. 2, pp. 74–78, 2003, [Online]. Available: https://sid.ir/paper/275194/en

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