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Information Journal Paper

Title

MICRODOSE 14C UREA BREATH TEST FOR THE DIAGNOSIS OF HELICOBACTER PYLORI: A SURVEY IN IRANIAN POPULATION

Pages

  6-40

Abstract

 The carbon -14 UREA BREATH TEST (UBT)is a non-invasive and simple method for the diagnosis of HELICOBACTER PYLORI infection. Attempts have been made to use lower doses of 14C-urea in the UBT in order to reduce the radiation risk of the test. The aim of this study was to assess the accuracy of a MICRODOSE (1 µCi [37 KBq]) 14C-UBT in Iranian population for validation of its diagnostic accuracy against gold standard methods. Eighty and two patients were subjected to upper gastrointestinal endoscopy as well as 14C-UBT in one week. Rapid urease test and histological examinations were used as gold standard. Breath samples were collected 10, 20 and 30 minute after ingestion of 1 µCi of 14C- urea solution and their activities were measured using a scintillation counter and expressed as counts per minute (cpm) and disintegration per minute (dpm). Good agreement was observed between the 14C-UBT and gold standard for samples which were collected 20 minutes after 14C-urea administration. The 14CUBT showed 100% sensitivity, 95% specificity, 95.45% positive predictive value, 100% negative predictive value and 97.50% accuracy. The results of this study showed good concordance between the 14C-UBT and invasive methods.

Cites

References

Cite

APA: Copy

DOWLATABADI BAZAZ, R., KHALAJ, A., BEYKI, D., EFTEKHARI, MEHRDAD, AL-SEYED HOSEIN, M.H., & KHOUSHAYAND, M.R.. (2005). MICRODOSE 14C UREA BREATH TEST FOR THE DIAGNOSIS OF HELICOBACTER PYLORI: A SURVEY IN IRANIAN POPULATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 13(1), 6-40. SID. https://sid.ir/paper/275230/en

Vancouver: Copy

DOWLATABADI BAZAZ R., KHALAJ A., BEYKI D., EFTEKHARI MEHRDAD, AL-SEYED HOSEIN M.H., KHOUSHAYAND M.R.. MICRODOSE 14C UREA BREATH TEST FOR THE DIAGNOSIS OF HELICOBACTER PYLORI: A SURVEY IN IRANIAN POPULATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2005;13(1):6-40. Available from: https://sid.ir/paper/275230/en

IEEE: Copy

R. DOWLATABADI BAZAZ, A. KHALAJ, D. BEYKI, MEHRDAD EFTEKHARI, M.H. AL-SEYED HOSEIN, and M.R. KHOUSHAYAND, “MICRODOSE 14C UREA BREATH TEST FOR THE DIAGNOSIS OF HELICOBACTER PYLORI: A SURVEY IN IRANIAN POPULATION,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 13, no. 1, pp. 6–40, 2005, [Online]. Available: https://sid.ir/paper/275230/en

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