EVALUATION OF TUMOR TARGETING WITH RADIOLABELED F(AB)2 FRAGMENT OF A HUMANIZED MONOCLONAL ANTIBODY

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BABAEI M.H.; FARSHID FAR R.; NAJAFI R.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2002 | Volume:10 | Issue:2 Page(s): 49-53

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Title

EVALUATION OF TUMOR TARGETING WITH RADIOLABELED F(AB)2 FRAGMENT OF A HUMANIZED MONOCLONAL ANTIBODY

Author(s)

BABAEI M.H. | FARSHID FAR R. | NAJAFI R. | Issue Writer Certificate

Keywords

HUMANIZED MONOCLONAL ANTIBODY

F(AB')2 FRAGMENT

I-125

Abstract

HUMANIZED MONOCLONAL ANTIBODY U36 and its F(ab')2 fragment, radio labeled with 125I, were tested for tumor localization in nude mice bearing a squamous cell carcinoma xenograft line derived from a head and neck carcinoma. Monoclonal antibody IgG or F(ab')2 fragment were injected in parallel and at days 1, 2 and 3, mice were dissected for determination of isotope biodistribution. IgG as well as F(ab')2 showed highly specific localization in tumor tissue. The mean tumor uptake (n=3) is expressed as the percentage of the injected dose per gram of tumor tissue (%ID/g). %ID/g of IgG was 11.7% at day 1 and decreased to 10.9% at day 3 whereas %ID/g of F(ab')2 was 2.9% at day 1 and decreased on following days. Tumor to blood ratios (T/B) at day 1 were 0.86 for IgG and 1.32 for F(ab')2 and reached a maximum at day 3 with values of 4.41 and 1.84 respectively. These findings suggest that the superior tumor to non-tumor ratios in the day of 1 render the F(ab')2 fragment more qualified for specific targeting radioisotopes to tumor xenografts in this exprimental setting.

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APA: Copy

BABAEI, M.H., FARSHID FAR, R., & NAJAFI, R.. (2002). EVALUATION OF TUMOR TARGETING WITH RADIOLABELED F(AB)2 FRAGMENT OF A HUMANIZED MONOCLONAL ANTIBODY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 10(2), 49-53. SID. https://sid.ir/paper/275248/en

Vancouver: Copy

BABAEI M.H., FARSHID FAR R., NAJAFI R.. EVALUATION OF TUMOR TARGETING WITH RADIOLABELED F(AB)2 FRAGMENT OF A HUMANIZED MONOCLONAL ANTIBODY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2002;10(2):49-53. Available from: https://sid.ir/paper/275248/en

IEEE: Copy

M.H. BABAEI, R. FARSHID FAR, and R. NAJAFI, “EVALUATION OF TUMOR TARGETING WITH RADIOLABELED F(AB)2 FRAGMENT OF A HUMANIZED MONOCLONAL ANTIBODY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 10, no. 2, pp. 49–53, 2002, [Online]. Available: https://sid.ir/paper/275248/en

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