PREPARATION OF TESTOSTERONE USING MICROBIAL METABOLITE OF CHOLESTEROL

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NAGHIBI F.; TABATABAEI YAZDI S.M.; SHAHHOSSEINI S.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2002 | Volume:10 | Issue:2 Page(s): 70-73

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Information Journal Paper

Title

PREPARATION OF TESTOSTERONE USING MICROBIAL METABOLITE OF CHOLESTEROL

Author(s)

NAGHIBI F. | TABATABAEI YAZDI S.M. | SHAHHOSSEINI S. | Issue Writer Certificate

Keywords

MYCOBACTERIUM SMEGMATIS

TESTOSTERONE

CHOLESTEROL

SODIUM BOROHYDRIDE

Abstract

Natural sterols are potential raw materials for the preparation of pharmacologically active steroid products. This paper details preparation of TESTOSTERONE, one of the steroidal hormones, through microbial metabolism of CHOLESTEROL followed by chemical reduction. The side chain of CHOLESTEROL was selectively cleaved by MYCOBACTERIUM SMEGMATIS PTCC 1307, and then selective reduction of resulting 17-keton group of androst-4-ene-3, 17-dione (AD), the main product of microbial transformation, with SODIUM BOROHYDRIDE at -10°C gave TESTOSTERONE in high yield (90%). Assignment of structures was made by IR, NMR, Mass, and UV spectroscopic data.

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APA: Copy

NAGHIBI, F., TABATABAEI YAZDI, S.M., & SHAHHOSSEINI, S.. (2002). PREPARATION OF TESTOSTERONE USING MICROBIAL METABOLITE OF CHOLESTEROL. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 10(2), 70-73. SID. https://sid.ir/paper/275249/en

Vancouver: Copy

NAGHIBI F., TABATABAEI YAZDI S.M., SHAHHOSSEINI S.. PREPARATION OF TESTOSTERONE USING MICROBIAL METABOLITE OF CHOLESTEROL. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2002;10(2):70-73. Available from: https://sid.ir/paper/275249/en

IEEE: Copy

F. NAGHIBI, S.M. TABATABAEI YAZDI, and S. SHAHHOSSEINI, “PREPARATION OF TESTOSTERONE USING MICROBIAL METABOLITE OF CHOLESTEROL,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 10, no. 2, pp. 70–73, 2002, [Online]. Available: https://sid.ir/paper/275249/en

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