ASSESSMENT OF DIFFERENT BIOEQUIVALENT METRICS IN RIFAMPIN BIOEQUIVALENCE STUDY

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ROUINI M.R.; TAJERZADEH H.; VALADKHANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2002 | Volume:10 | Issue:2 Page(s): 54-57

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Information Journal Paper

Title

ASSESSMENT OF DIFFERENT BIOEQUIVALENT METRICS IN RIFAMPIN BIOEQUIVALENCE STUDY

Author(s)

ROUINI M.R. | TAJERZADEH H. | VALADKHANI M. | Issue Writer Certificate

Keywords

BIOEQUIVALENCE

SECONDARY METRICS

TRUNCATED AUC

PARTIAL AREA METHOD

CMAX/AUC

RIFAMPIN

Abstract

The use of SECONDARY METRICS has become special interest in bioequivalency studies. The applicability of partial area method, TRUNCATED AUC and CMAX/AUC has been argued by many authors. This study aims to evaluate the possible superiority of these metrics to primary metrics (i.e. AUCinf, Cmax and Tmax). The suitability of TRUNCATED AUC for assessment of absorption extent as well as CMAX/AUC and partial AUC for the evaluation of absorption rate in bioequivalency determination was investigated following administration of same product as test and reference to 7 healthy volunteers. Among the pharmacokinetic parameters obtained, Cmax/AUCinf was a better indicator or absorption rate and the AUCinf was more sensitive than TRUNCATED AUC in evaluation of absorption extent.

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APA: Copy

ROUINI, M.R., TAJERZADEH, H., & VALADKHANI, M.. (2002). ASSESSMENT OF DIFFERENT BIOEQUIVALENT METRICS IN RIFAMPIN BIOEQUIVALENCE STUDY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 10(2), 54-57. SID. https://sid.ir/paper/275250/en

Vancouver: Copy

ROUINI M.R., TAJERZADEH H., VALADKHANI M.. ASSESSMENT OF DIFFERENT BIOEQUIVALENT METRICS IN RIFAMPIN BIOEQUIVALENCE STUDY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2002;10(2):54-57. Available from: https://sid.ir/paper/275250/en

IEEE: Copy

M.R. ROUINI, H. TAJERZADEH, and M. VALADKHANI, “ASSESSMENT OF DIFFERENT BIOEQUIVALENT METRICS IN RIFAMPIN BIOEQUIVALENCE STUDY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 10, no. 2, pp. 54–57, 2002, [Online]. Available: https://sid.ir/paper/275250/en

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