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Information Journal Paper

Title

IS ALBENDAZOLE SULPHONATION DOSE DEPENDENT IN HUMAN?

Pages

  148-152

Abstract

 Phannacokinetics of ALBENDAZOLE sulphone in three different single oral doses of ALBENDAZOLE (ABZ) (400, 800 & l200mg) in 10 healthy human volunteers in a double blind three-way crossover design. were studied. The serum levels of the main metabolites of ABZ (ALBENDAZOLE sulphoxide (ABZ-SO) and ALBENDAZOLE sulphone (ABZ-So2)) were analyzed by a modified high-pressure liquid chromatography method. For both metabolites, there were no significant differences in the biological half life, normalized serum peak concentration (Cmax/Dose) and time to reach peak concentration (Tmax). However apparent learance (Clp/F), apparent distribution volume (Vd/F), normalized area under the serum concentration- time curve (AUC/Dose) and normalized area under the first moment curve (AUMC/Dose) of ALBENDAZOLE metabolites were statistically different for various doses, resulting in substantially lower serum concentration and thereafter lower AUC/Dose and AUMC/Dose in higher doses. Ratios of pharmacokinetic parameters of ABZ-SO to those of ABZ-So2 were calculated and there were no significant differences for various ABZ doses. It is concluded that dose dependent PHARMACOKINETICS of ABZ- So2 results from dose dependency of the PHARMACOKINETICS of ABZ-SO, on the basis of a change in fraction of absorbed dose (F) as a result of slow and incomplete dissolution of the main drug in the GI tract. It is also concluded that in the subjects under study sulphonation of ABZ-SO was not dose dependent

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    Cite

    APA: Copy

    ROUINI, M.R., MIR FAZAELIAN, A., DADASHZADEH, S., & TABATABAEIFAR, M.. (2002). IS ALBENDAZOLE SULPHONATION DOSE DEPENDENT IN HUMAN? . DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 10(4), 148-152. SID. https://sid.ir/paper/275262/en

    Vancouver: Copy

    ROUINI M.R., MIR FAZAELIAN A., DADASHZADEH S., TABATABAEIFAR M.. IS ALBENDAZOLE SULPHONATION DOSE DEPENDENT IN HUMAN? . DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2002;10(4):148-152. Available from: https://sid.ir/paper/275262/en

    IEEE: Copy

    M.R. ROUINI, A. MIR FAZAELIAN, S. DADASHZADEH, and M. TABATABAEIFAR, “IS ALBENDAZOLE SULPHONATION DOSE DEPENDENT IN HUMAN? ,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 10, no. 4, pp. 148–152, 2002, [Online]. Available: https://sid.ir/paper/275262/en

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