ASSESSMENT OF HUMAN AT1 BINDING AFFINITY OF SOME NOVEL 2-ALKYLTHIO-1-[4-(N-ALPHA-ETHOXYCARBONYL-NZYL)AMINOBENZYL-5-HYDROXYMETHYLIMIDAZOLES

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BADAKHSHANNOORY S.; HADIZADEH F.; SHAFIEI A.

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2004 | Volume:12 | Issue:1 Page(s): 31-35

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Title

ASSESSMENT OF HUMAN AT1 BINDING AFFINITY OF SOME NOVEL 2-ALKYLTHIO-1-[4-(N-ALPHA-ETHOXYCARBONYL-NZYL)AMINOBENZYL-5-HYDROXYMETHYLIMIDAZOLES

Author(s)

BADAKHSHANNOORY S. | HADIZADEH F. | SHAFIEI A. | Issue Writer Certificate

Keywords

RENIN-ANGIOTENSIN SYSTEM

ANGIOTENSINII

LOSARTAN

PHENOXYPHENYLACETIC ACID

RADIOLIGAND BINDING ASSAY

Abstract

Antagonists of various components of the RENIN-ANGIOTENSIN SYSTEM have been the subject of many studies for the control of blood pressure. Compounds with a PHENOXYPHENYLACETIC ACID moiety that mimic the structure of LOSARTAN which is a powerful competitive antagonist of angiotensin receptor, have shown to be effective. In this study, the affinity of some 2-alkylthio-1-[4-(N-α-ethoxycarbonylbenzyl) aminobenzyl]-5-hydroxymethyl imidazoles for the human AT1 receptor was assessed in a RADIOLIGAND BINDING ASSAY. It was found that an alkyl chain of appropriate length would be most suitable if situated on the imidazole ring. Furthermore, variations of the lower phenyl rings demonstrated that introduction of a methyl group in this position will account for the most desired effect.

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APA: Copy

BADAKHSHANNOORY, S., HADIZADEH, F., & SHAFIEI, A.. (2004). ASSESSMENT OF HUMAN AT1 BINDING AFFINITY OF SOME NOVEL 2-ALKYLTHIO-1-[4-(N-ALPHA-ETHOXYCARBONYL-NZYL)AMINOBENZYL-5-HYDROXYMETHYLIMIDAZOLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 12(1), 31-35. SID. https://sid.ir/paper/275272/en

Vancouver: Copy

BADAKHSHANNOORY S., HADIZADEH F., SHAFIEI A.. ASSESSMENT OF HUMAN AT1 BINDING AFFINITY OF SOME NOVEL 2-ALKYLTHIO-1-[4-(N-ALPHA-ETHOXYCARBONYL-NZYL)AMINOBENZYL-5-HYDROXYMETHYLIMIDAZOLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2004;12(1):31-35. Available from: https://sid.ir/paper/275272/en

IEEE: Copy

S. BADAKHSHANNOORY, F. HADIZADEH, and A. SHAFIEI, “ASSESSMENT OF HUMAN AT1 BINDING AFFINITY OF SOME NOVEL 2-ALKYLTHIO-1-[4-(N-ALPHA-ETHOXYCARBONYL-NZYL)AMINOBENZYL-5-HYDROXYMETHYLIMIDAZOLES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 12, no. 1, pp. 31–35, 2004, [Online]. Available: https://sid.ir/paper/275272/en

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