PHARMACODYNAMICALLY EVALUATED BIOEQUIVALENCE OF TWO PREPARATIONS OF ENALAPRIL MALEATE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAJERZADEH H.; HAMIDI M.; ROUINI M.R.; SHAHVERDI M.; GHAIUMI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2001 | Volume:9 | Issue:1-2 Page(s): 23-27

Download Full-Text

View:

332

Download:

173

Cites:

Information Journal Paper

Title

PHARMACODYNAMICALLY EVALUATED BIOEQUIVALENCE OF TWO PREPARATIONS OF ENALAPRIL MALEATE

Author(s)

Keywords

ENALAPRIL MALEATE

BIOEQUIVALENCE

ACE

ACE INHIBITORS

CLINICAL STUDY

Abstract

The BIOEQUIVALENCE of two preparations of ENALAPRIL MALEATE (20 mg tablets) manufactured in Iran has been exploited in reference to a standard preparation (Xanef 20 tablets, MSD, Germany) in 14 healthy volunteers. Following oral dosing of a single tablet of each of test and standard products, as a randomized crossover design with 10-day washout intervals, the blood samples were collected in predetermined time points and using a synthetic substrate, Hippuryl-Histidy-Leucine (HHL), the release of hippuric acid from the substrate was determined as Angiotensin-Converting-Enzyme (ACE) activity of serum fractions. The percent of ACE inhibition in each sample was calculated and plotted against time, from which three pharmacodynamic parameters, i.e. Emax, tmax and AUC0-24 were derived. The results of statistical comparison of these parameters showed that both of the test preparations are bioequivalent with reference standard preparation.

Cites

No record.

References

Cite

APA: Copy

TAJERZADEH, H., HAMIDI, M., ROUINI, M.R., SHAHVERDI, M., & GHAIUMI, A.. (2001). PHARMACODYNAMICALLY EVALUATED BIOEQUIVALENCE OF TWO PREPARATIONS OF ENALAPRIL MALEATE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 9(1-2), 23-27. SID. https://sid.ir/paper/275278/en

Vancouver: Copy

TAJERZADEH H., HAMIDI M., ROUINI M.R., SHAHVERDI M., GHAIUMI A.. PHARMACODYNAMICALLY EVALUATED BIOEQUIVALENCE OF TWO PREPARATIONS OF ENALAPRIL MALEATE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2001;9(1-2):23-27. Available from: https://sid.ir/paper/275278/en

IEEE: Copy

H. TAJERZADEH, M. HAMIDI, M.R. ROUINI, M. SHAHVERDI, and A. GHAIUMI, “PHARMACODYNAMICALLY EVALUATED BIOEQUIVALENCE OF TWO PREPARATIONS OF ENALAPRIL MALEATE,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 9, no. 1-2, pp. 23–27, 2001, [Online]. Available: https://sid.ir/paper/275278/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops